Gene duplication and evolutionary innovations in hemoglobin-oxygen transport

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

During vertebrate evolution, duplicated hemoglobin (Hb) genes diverged with respect to functional properties as well as the developmental timing of expression. For example, the subfamilies of genes that encode the different subunit chains of Hb are ontogenetically regulated such that functionally distinct Hb isoforms are expressed during different developmental stages. In some vertebrate taxa, functional differentiation between co-expressed Hb isoforms may also contribute to physiologically important divisions of labor.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalPhysiology
Volume31
Issue number3
DOIs
StatePublished - May 1 2016

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Gene Duplication
Hemoglobins
Oxygen
Vertebrates
Protein Isoforms
Hemoglobin Subunits
Genes

ASJC Scopus subject areas

  • Physiology

Cite this

Gene duplication and evolutionary innovations in hemoglobin-oxygen transport. / Storz, Jay F.

In: Physiology, Vol. 31, No. 3, 01.05.2016, p. 223-232.

Research output: Contribution to journalReview article

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