Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection

A review of current diagnosis and management

Qinglong Hu, Yizhuo Zhang, Xiaoyan Zhang, Kai Fu

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.

Original languageEnglish (US)
Article number15
JournalBiomarker Research
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Marginal Zone B-Cell Lymphoma
Helicobacter Infections
Gastric Mucosa
Helicobacter pylori
Cells
Tissue
Chemotherapy
Radiotherapy
B-Lymphocytes
Refractory materials
Anti-Bacterial Agents
B-Cell Lymphoma
Gastritis
Communicable Diseases
Lymphoma
China
Mucous Membrane
Staining and Labeling
Drug Therapy
Familial primary gastric lymphoma

Keywords

  • Gastric MALT
  • Helicobacter pylori

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection : A review of current diagnosis and management. / Hu, Qinglong; Zhang, Yizhuo; Zhang, Xiaoyan; Fu, Kai.

In: Biomarker Research, Vol. 4, No. 1, 15, 01.01.2016.

Research output: Contribution to journalReview article

@article{516a8e3275bc4b8a8a83c7b255d0c898,
title = "Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: A review of current diagnosis and management",
abstract = "Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.",
keywords = "Gastric MALT, Helicobacter pylori",
author = "Qinglong Hu and Yizhuo Zhang and Xiaoyan Zhang and Kai Fu",
year = "2016",
month = "1",
day = "1",
doi = "10.1186/s40364-016-0068-1",
language = "English (US)",
volume = "4",
journal = "Biomarker Research",
issn = "2050-7771",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection

T2 - A review of current diagnosis and management

AU - Hu, Qinglong

AU - Zhang, Yizhuo

AU - Zhang, Xiaoyan

AU - Fu, Kai

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.

AB - Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.

KW - Gastric MALT

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=85040008854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040008854&partnerID=8YFLogxK

U2 - 10.1186/s40364-016-0068-1

DO - 10.1186/s40364-016-0068-1

M3 - Review article

VL - 4

JO - Biomarker Research

JF - Biomarker Research

SN - 2050-7771

IS - 1

M1 - 15

ER -