Gap-junction protein gene suppresses tumorigenicity

Birgit Rose, Parmender P. Mehta, Werner R. Loewenstein

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the α1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell-cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.

Original languageEnglish (US)
Pages (from-to)1073-1075
Number of pages3
JournalCarcinogenesis
Volume14
Issue number5
DOIs
StatePublished - May 1 1993

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Gap Junction
Connexins
Genes
Gene
Proteins
Protein
Cell
Mouse
Rats
Cell Communication
Rat Heart
Connexin 43
Gap Junctions
Membranes
Growth
Ion Channels
Nude Mice
Communication
Genome
Membrane

ASJC Scopus subject areas

  • Cancer Research

Cite this

Rose, B., Mehta, P. P., & Loewenstein, W. R. (1993). Gap-junction protein gene suppresses tumorigenicity. Carcinogenesis, 14(5), 1073-1075. https://doi.org/10.1093/carcin/14.5.1073

Gap-junction protein gene suppresses tumorigenicity. / Rose, Birgit; Mehta, Parmender P.; Loewenstein, Werner R.

In: Carcinogenesis, Vol. 14, No. 5, 01.05.1993, p. 1073-1075.

Research output: Contribution to journalArticle

Rose, B, Mehta, PP & Loewenstein, WR 1993, 'Gap-junction protein gene suppresses tumorigenicity', Carcinogenesis, vol. 14, no. 5, pp. 1073-1075. https://doi.org/10.1093/carcin/14.5.1073
Rose, Birgit ; Mehta, Parmender P. ; Loewenstein, Werner R. / Gap-junction protein gene suppresses tumorigenicity. In: Carcinogenesis. 1993 ; Vol. 14, No. 5. pp. 1073-1075.
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