Galactose, glucose, and lactate concentrations in the portal venous and arterial circulations of newborn lambs after nursing

Joseph W. Kaempf, Hai Qi Li, Jessie R. Groothuis, Frederick C. Battaglia, Gary O. Zerbe, John W. Sparks

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have used the newborn lamb prepared with chronic indwelling catheters to study carbohydrate metabolism in the unstressed, postprandial state. Lambs were fasted 5 h and then allowed to nurse ad libitum from their mothers for 20 min. Serial determinations of whole blood galactose, glucose, and lactate concentration were then made from the portal venous and arterial circulations. Portal venous galactose concentration increased significantly after milk ingestion, but arterial galactose concentration did not increase from baseline unless the portal venous galactose concentration exceeded 10-12 mg/dl sug­gesting a threshold effect for hepatic galactose clearance. Glucose concentration increased significantly in both circulations with portal venous galactose concentration > arterial galactose concentration in all cases. Galactose and glucose were absorbed from the intestine at approximately equal rates. Lactate was not absorbed into the portal venous circulation to any great extent after lactose ingestion.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalPediatric Research
Volume23
Issue number6
DOIs
StatePublished - Jun 1988

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Galactose
Lactic Acid
Nursing
Newborn Infant
Glucose
Eating
Indwelling Catheters
Carbohydrate Metabolism
Lactose
Intestines
Blood Glucose
Milk
Nurses
Mothers
Liver

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Galactose, glucose, and lactate concentrations in the portal venous and arterial circulations of newborn lambs after nursing. / Kaempf, Joseph W.; Li, Hai Qi; Groothuis, Jessie R.; Battaglia, Frederick C.; Zerbe, Gary O.; Sparks, John W.

In: Pediatric Research, Vol. 23, No. 6, 06.1988, p. 598-602.

Research output: Contribution to journalArticle

Kaempf, Joseph W. ; Li, Hai Qi ; Groothuis, Jessie R. ; Battaglia, Frederick C. ; Zerbe, Gary O. ; Sparks, John W. / Galactose, glucose, and lactate concentrations in the portal venous and arterial circulations of newborn lambs after nursing. In: Pediatric Research. 1988 ; Vol. 23, No. 6. pp. 598-602.
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