Gait variability measures reveal differences between multiple sclerosis patients and healthy controls

Jeffrey P. Kaipust, Jessie M. Huisinga, Mary Filipi, Nicholas Stergiou

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The purpose of this study was to determine the differences in gait variability between patients with multiple sclerosis (MS) and healthy controls during walking at a self-selected pace. Methods: Kinematics were collected during three minutes of treadmill walking for 10 patients with MS and 10 healthy controls. The Coefficient of Variation (CoV), the Approximate Entropy (ApEn) and the Detrended Fluctuation Analysis (DFA) were used to investigate the fluctuations present in stride length and step width from continuous strides. Results: ApEn revealed that patients with MS had significantly lower values than healthy controls for stride length (p < .001) and step width (p < .001). Conclusions: ApEn results revealed that the natural fluctuations present during gait in the stride length and step width time series are more regular and repeatable in patients with MS. These changes implied that patients with MS may exhibit reduced capacity to adapt and respond to perturbations during gait.

Original languageEnglish (US)
Pages (from-to)229-244
Number of pages16
JournalMotor Control
Volume16
Issue number2
DOIs
StatePublished - 2012

Fingerprint

Gait
Multiple Sclerosis
Entropy
Walking
Biomechanical Phenomena

Keywords

  • Gait variability
  • Multiple sclerosis
  • Nonlinear dynamics
  • Step width
  • Stride length

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Clinical Neurology
  • Physiology (medical)

Cite this

Gait variability measures reveal differences between multiple sclerosis patients and healthy controls. / Kaipust, Jeffrey P.; Huisinga, Jessie M.; Filipi, Mary; Stergiou, Nicholas.

In: Motor Control, Vol. 16, No. 2, 2012, p. 229-244.

Research output: Contribution to journalArticle

Kaipust, Jeffrey P. ; Huisinga, Jessie M. ; Filipi, Mary ; Stergiou, Nicholas. / Gait variability measures reveal differences between multiple sclerosis patients and healthy controls. In: Motor Control. 2012 ; Vol. 16, No. 2. pp. 229-244.
@article{747aa727b95d4002ae74b323b27c6dad,
title = "Gait variability measures reveal differences between multiple sclerosis patients and healthy controls",
abstract = "The purpose of this study was to determine the differences in gait variability between patients with multiple sclerosis (MS) and healthy controls during walking at a self-selected pace. Methods: Kinematics were collected during three minutes of treadmill walking for 10 patients with MS and 10 healthy controls. The Coefficient of Variation (CoV), the Approximate Entropy (ApEn) and the Detrended Fluctuation Analysis (DFA) were used to investigate the fluctuations present in stride length and step width from continuous strides. Results: ApEn revealed that patients with MS had significantly lower values than healthy controls for stride length (p < .001) and step width (p < .001). Conclusions: ApEn results revealed that the natural fluctuations present during gait in the stride length and step width time series are more regular and repeatable in patients with MS. These changes implied that patients with MS may exhibit reduced capacity to adapt and respond to perturbations during gait.",
keywords = "Gait variability, Multiple sclerosis, Nonlinear dynamics, Step width, Stride length",
author = "Kaipust, {Jeffrey P.} and Huisinga, {Jessie M.} and Mary Filipi and Nicholas Stergiou",
year = "2012",
doi = "10.1123/mcj.16.2.229",
language = "English (US)",
volume = "16",
pages = "229--244",
journal = "Motor Control",
issn = "1087-1640",
publisher = "Human Kinetics Publishers Inc.",
number = "2",

}

TY - JOUR

T1 - Gait variability measures reveal differences between multiple sclerosis patients and healthy controls

AU - Kaipust, Jeffrey P.

AU - Huisinga, Jessie M.

AU - Filipi, Mary

AU - Stergiou, Nicholas

PY - 2012

Y1 - 2012

N2 - The purpose of this study was to determine the differences in gait variability between patients with multiple sclerosis (MS) and healthy controls during walking at a self-selected pace. Methods: Kinematics were collected during three minutes of treadmill walking for 10 patients with MS and 10 healthy controls. The Coefficient of Variation (CoV), the Approximate Entropy (ApEn) and the Detrended Fluctuation Analysis (DFA) were used to investigate the fluctuations present in stride length and step width from continuous strides. Results: ApEn revealed that patients with MS had significantly lower values than healthy controls for stride length (p < .001) and step width (p < .001). Conclusions: ApEn results revealed that the natural fluctuations present during gait in the stride length and step width time series are more regular and repeatable in patients with MS. These changes implied that patients with MS may exhibit reduced capacity to adapt and respond to perturbations during gait.

AB - The purpose of this study was to determine the differences in gait variability between patients with multiple sclerosis (MS) and healthy controls during walking at a self-selected pace. Methods: Kinematics were collected during three minutes of treadmill walking for 10 patients with MS and 10 healthy controls. The Coefficient of Variation (CoV), the Approximate Entropy (ApEn) and the Detrended Fluctuation Analysis (DFA) were used to investigate the fluctuations present in stride length and step width from continuous strides. Results: ApEn revealed that patients with MS had significantly lower values than healthy controls for stride length (p < .001) and step width (p < .001). Conclusions: ApEn results revealed that the natural fluctuations present during gait in the stride length and step width time series are more regular and repeatable in patients with MS. These changes implied that patients with MS may exhibit reduced capacity to adapt and respond to perturbations during gait.

KW - Gait variability

KW - Multiple sclerosis

KW - Nonlinear dynamics

KW - Step width

KW - Stride length

UR - http://www.scopus.com/inward/record.url?scp=84861173559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861173559&partnerID=8YFLogxK

U2 - 10.1123/mcj.16.2.229

DO - 10.1123/mcj.16.2.229

M3 - Article

C2 - 22615327

AN - SCOPUS:84861173559

VL - 16

SP - 229

EP - 244

JO - Motor Control

JF - Motor Control

SN - 1087-1640

IS - 2

ER -