GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases

Marco Antônio Peliky Fontes, Gisele Cristiane Vaz, Thais Zielke Dias Cardoso, Mariana Flávia de Oliveira, Maria José Campagnole-Santos, Robson Augusto Souza dos Santos, Neeru M. Sharma, Kaushik P. Patel, Frédéric Frézard

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.

Original languageEnglish (US)
Pages (from-to)781-788
Number of pages8
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume14
Issue number3
DOIs
StatePublished - Apr 2018

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Keywords

  • GABA
  • Liposomes
  • Nervous system
  • Neurological diseases
  • Neuroscience

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Fontes, M. A. P., Vaz, G. C., Cardoso, T. Z. D., de Oliveira, M. F., Campagnole-Santos, M. J., dos Santos, R. A. S., Sharma, N. M., Patel, K. P., & Frézard, F. (2018). GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases. Nanomedicine: Nanotechnology, Biology, and Medicine, 14(3), 781-788. https://doi.org/10.1016/j.nano.2017.12.007