G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells

Hong Xin, Rongze Lu, Heehyoung Lee, Wang Zhang, Chunyan Zhang, Jiehui Deng, Yong Liu, Shudan Shen, Kay Uwe Wagner, Stephen Forman, Richard Jove, Hua Yu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Signaling pathways underlying BV8-mediated oncogenesis remain unknown. Results: BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth. Conclusion: JAK2/STAT3 signaling plays critical roles in BV8-mediated myeloid cell-dependent oncogenesis. Significance: This study identifies a novel role of BV8-STAT3 signaling in mediating cross-talk between tumor microenvironment and tumor cells.

Original languageEnglish (US)
Pages (from-to)13842-13849
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
StatePublished - May 10 2013

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STAT3 Transcription Factor
Myeloid Cells
G-Protein-Coupled Receptors
Tumors
Carcinogenesis
Tumor Microenvironment
Neoplasms
Growth
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. / Xin, Hong; Lu, Rongze; Lee, Heehyoung; Zhang, Wang; Zhang, Chunyan; Deng, Jiehui; Liu, Yong; Shen, Shudan; Wagner, Kay Uwe; Forman, Stephen; Jove, Richard; Yu, Hua.

In: Journal of Biological Chemistry, Vol. 288, No. 19, 10.05.2013, p. 13842-13849.

Research output: Contribution to journalArticle

Xin, H, Lu, R, Lee, H, Zhang, W, Zhang, C, Deng, J, Liu, Y, Shen, S, Wagner, KU, Forman, S, Jove, R & Yu, H 2013, 'G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells', Journal of Biological Chemistry, vol. 288, no. 19, pp. 13842-13849. https://doi.org/10.1074/jbc.M113.450049
Xin, Hong ; Lu, Rongze ; Lee, Heehyoung ; Zhang, Wang ; Zhang, Chunyan ; Deng, Jiehui ; Liu, Yong ; Shen, Shudan ; Wagner, Kay Uwe ; Forman, Stephen ; Jove, Richard ; Yu, Hua. / G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 19. pp. 13842-13849.
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AU - Zhang, Wang

AU - Zhang, Chunyan

AU - Deng, Jiehui

AU - Liu, Yong

AU - Shen, Shudan

AU - Wagner, Kay Uwe

AU - Forman, Stephen

AU - Jove, Richard

AU - Yu, Hua

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