G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood

Craig L Semerad, Fulu Liu, Alyssa D. Gregory, Katherine Stumpf, Daniel C. Link

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses, including infection. We show that under basal conditions granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil release from the bone marrow. Nonredundant signals generated by the membrane-proximal 87 amino acids of the G-CSF receptor (G-CSFR) are sufficient to mediate this response. Surprisingly, G-CSFR expression on neutrophils is neither necessary nor sufficient for their mobilization from the bone marrow, suggesting that G-CSF induces neutrophil mobilization indirectly through the generation of trans-acting signals. Evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone marrow may represent such a signal.

Original languageEnglish (US)
Pages (from-to)413-423
Number of pages11
JournalImmunity
Volume17
Issue number4
DOIs
StatePublished - Oct 1 2002

Fingerprint

Granulocyte Colony-Stimulating Factor
Neutrophils
Granulocyte Colony-Stimulating Factor Receptors
Bone Marrow
Chemokine CXCL12
Physiological Stress
Down-Regulation
Amino Acids
Membranes
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. / Semerad, Craig L; Liu, Fulu; Gregory, Alyssa D.; Stumpf, Katherine; Link, Daniel C.

In: Immunity, Vol. 17, No. 4, 01.10.2002, p. 413-423.

Research output: Contribution to journalArticle

Semerad, Craig L ; Liu, Fulu ; Gregory, Alyssa D. ; Stumpf, Katherine ; Link, Daniel C. / G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. In: Immunity. 2002 ; Vol. 17, No. 4. pp. 413-423.
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