G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood

Craig L. Semerad, Fulu Liu, Alyssa D. Gregory, Katherine Stumpf, Daniel C. Link

Research output: Contribution to journalArticle

247 Scopus citations

Abstract

Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses, including infection. We show that under basal conditions granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil release from the bone marrow. Nonredundant signals generated by the membrane-proximal 87 amino acids of the G-CSF receptor (G-CSFR) are sufficient to mediate this response. Surprisingly, G-CSFR expression on neutrophils is neither necessary nor sufficient for their mobilization from the bone marrow, suggesting that G-CSF induces neutrophil mobilization indirectly through the generation of trans-acting signals. Evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone marrow may represent such a signal.

Original languageEnglish (US)
Pages (from-to)413-423
Number of pages11
JournalImmunity
Volume17
Issue number4
DOIs
StatePublished - Oct 1 2002

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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