Future role of MR elastography in tissue engineering and regenerative medicine

Shadi F. Othman, Huihui Xu, Jeremy J. Mao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tissue engineering (TE) has been introduced for more than 25 years without a boom in clinical trials. More than 70 TE-related start-up companies spent more than $600 million/year, with only two FDA-approved tissue-engineered products. Given the modest performance in clinically approved organs, TE is a tenaciously promising field. The TE community is advocating the application of clinically driven methodologies in large animal models enabling clinical translation. This challenge is hindered by the scarcity of tissue biopsies and the absence of standardized evaluation tools, but can be negated through non-invasive assessment of growth and integration, with reduced sample size and low cost. Solving this issue will speed the transition to cost-efficient clinical studies. In this paper we: (a) introduce magnetic resonance elastography to the tissue-engineering and regenerative medicine (TERM) community; (b) review recent MRE applications in TERM; and (c) discuss future directions of MRE in TERM. We have used MRE to study engineered tissues both in vitro and in vivo, where the mechanical properties of mesenchymally derived constructs were progressively monitored before and after tissues were implanted in mouse models. This study represents a stepping stone toward the applications of MRE in directing clinical trials with low cost and likely expediting the translation to more relevantly large animal models and clinical trials.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Elasticity Imaging Techniques
Regenerative Medicine
Tissue Engineering
Tissue engineering
Tissue
Clinical Trials
Costs and Cost Analysis
Animals
Animal Models
Costs
Biopsy
Magnetic resonance
Sample Size
Mechanical properties
Growth

Keywords

  • Animal models
  • Magnetic resonance elastography
  • Mechanical properties
  • Mesenchymally-derived constructs
  • Non-invasive monitoring
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Future role of MR elastography in tissue engineering and regenerative medicine. / Othman, Shadi F.; Xu, Huihui; Mao, Jeremy J.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 9, No. 5, 01.05.2015, p. 481-487.

Research output: Contribution to journalArticle

Othman, Shadi F. ; Xu, Huihui ; Mao, Jeremy J. / Future role of MR elastography in tissue engineering and regenerative medicine. In: Journal of Tissue Engineering and Regenerative Medicine. 2015 ; Vol. 9, No. 5. pp. 481-487.
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