Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

J. A. Bridge, M. Kanamori, Z. Ma, D. Pickering, D. A. Hill, W. Lydiatt, M. Y. Lui, G. W B Colleoni, C. R. Antonescu, M. Ladanyi, S. W. Morris

Research output: Contribution to journalArticle

259 Scopus citations

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46, XX, t(2;17)(p23;q23), add(16)(q24)].

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalAmerican Journal of Pathology
Volume159
Issue number2
DOIs
StatePublished - Jan 1 2001

    Fingerprint

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bridge, J. A., Kanamori, M., Ma, Z., Pickering, D., Hill, D. A., Lydiatt, W., Lui, M. Y., Colleoni, G. W. B., Antonescu, C. R., Ladanyi, M., & Morris, S. W. (2001). Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. American Journal of Pathology, 159(2), 411-415. https://doi.org/10.1016/S0002-9440(10)61711-7