Further observations on the effects of subhypnotic doses of midazolam in normal volunteers

E. F. Domino, Jeffrey A French, R. Pohorecki, C. F. Galus, S. K. Pandit

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Our studies on the effects of subhypnotic doses of midazolam in healthy adult volunteers have been extended with special emphasis on clinical electrophysiological endpoints of sedation and attention coupled with various tests of memory. We measured the many components of the P300 event-related brain potential to infrequent (rare) tones. Midazolam HCI was given in a dose of .02 mg/kg i.v. three times at approximately 15-minute intervals after obtaining baseline electrophysiological recordings and memory test results. Marked individual variation was observed with these small doses of midazolam. Some subjects were markedly sedated, whereas others showed relatively little sedation. Electroencephalogram (EEG) beta activity increased while alpha activity decreased following midazolam. Even though the subjects given midazolam were awake, there was a striking attention deficit that correlated well with the accuracy of counting rare tones and the alterations in various components of the late auditory event-related brain potential.

Original languageEnglish (US)
Pages (from-to)460-465
Number of pages6
JournalPsychopharmacology Bulletin
Volume25
Issue number3
StatePublished - Dec 1 1989

Fingerprint

Midazolam
Healthy Volunteers
P300 Event-Related Potentials
Brain
Evoked Potentials
Electroencephalography

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

Cite this

Domino, E. F., French, J. A., Pohorecki, R., Galus, C. F., & Pandit, S. K. (1989). Further observations on the effects of subhypnotic doses of midazolam in normal volunteers. Psychopharmacology Bulletin, 25(3), 460-465.

Further observations on the effects of subhypnotic doses of midazolam in normal volunteers. / Domino, E. F.; French, Jeffrey A; Pohorecki, R.; Galus, C. F.; Pandit, S. K.

In: Psychopharmacology Bulletin, Vol. 25, No. 3, 01.12.1989, p. 460-465.

Research output: Contribution to journalArticle

Domino, EF, French, JA, Pohorecki, R, Galus, CF & Pandit, SK 1989, 'Further observations on the effects of subhypnotic doses of midazolam in normal volunteers', Psychopharmacology Bulletin, vol. 25, no. 3, pp. 460-465.
Domino, E. F. ; French, Jeffrey A ; Pohorecki, R. ; Galus, C. F. ; Pandit, S. K. / Further observations on the effects of subhypnotic doses of midazolam in normal volunteers. In: Psychopharmacology Bulletin. 1989 ; Vol. 25, No. 3. pp. 460-465.
@article{ebe360c96ce848a1b3c3af6689c69589,
title = "Further observations on the effects of subhypnotic doses of midazolam in normal volunteers",
abstract = "Our studies on the effects of subhypnotic doses of midazolam in healthy adult volunteers have been extended with special emphasis on clinical electrophysiological endpoints of sedation and attention coupled with various tests of memory. We measured the many components of the P300 event-related brain potential to infrequent (rare) tones. Midazolam HCI was given in a dose of .02 mg/kg i.v. three times at approximately 15-minute intervals after obtaining baseline electrophysiological recordings and memory test results. Marked individual variation was observed with these small doses of midazolam. Some subjects were markedly sedated, whereas others showed relatively little sedation. Electroencephalogram (EEG) beta activity increased while alpha activity decreased following midazolam. Even though the subjects given midazolam were awake, there was a striking attention deficit that correlated well with the accuracy of counting rare tones and the alterations in various components of the late auditory event-related brain potential.",
author = "Domino, {E. F.} and French, {Jeffrey A} and R. Pohorecki and Galus, {C. F.} and Pandit, {S. K.}",
year = "1989",
month = "12",
day = "1",
language = "English (US)",
volume = "25",
pages = "460--465",
journal = "Psychopharmacology Bulletin",
issn = "0048-5764",
publisher = "MedWorks Media LLC",
number = "3",

}

TY - JOUR

T1 - Further observations on the effects of subhypnotic doses of midazolam in normal volunteers

AU - Domino, E. F.

AU - French, Jeffrey A

AU - Pohorecki, R.

AU - Galus, C. F.

AU - Pandit, S. K.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - Our studies on the effects of subhypnotic doses of midazolam in healthy adult volunteers have been extended with special emphasis on clinical electrophysiological endpoints of sedation and attention coupled with various tests of memory. We measured the many components of the P300 event-related brain potential to infrequent (rare) tones. Midazolam HCI was given in a dose of .02 mg/kg i.v. three times at approximately 15-minute intervals after obtaining baseline electrophysiological recordings and memory test results. Marked individual variation was observed with these small doses of midazolam. Some subjects were markedly sedated, whereas others showed relatively little sedation. Electroencephalogram (EEG) beta activity increased while alpha activity decreased following midazolam. Even though the subjects given midazolam were awake, there was a striking attention deficit that correlated well with the accuracy of counting rare tones and the alterations in various components of the late auditory event-related brain potential.

AB - Our studies on the effects of subhypnotic doses of midazolam in healthy adult volunteers have been extended with special emphasis on clinical electrophysiological endpoints of sedation and attention coupled with various tests of memory. We measured the many components of the P300 event-related brain potential to infrequent (rare) tones. Midazolam HCI was given in a dose of .02 mg/kg i.v. three times at approximately 15-minute intervals after obtaining baseline electrophysiological recordings and memory test results. Marked individual variation was observed with these small doses of midazolam. Some subjects were markedly sedated, whereas others showed relatively little sedation. Electroencephalogram (EEG) beta activity increased while alpha activity decreased following midazolam. Even though the subjects given midazolam were awake, there was a striking attention deficit that correlated well with the accuracy of counting rare tones and the alterations in various components of the late auditory event-related brain potential.

UR - http://www.scopus.com/inward/record.url?scp=0024812653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024812653&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 460

EP - 465

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

SN - 0048-5764

IS - 3

ER -