Fungal infections in liver transplant recipients

Charles P. Wajszczuk, J. Stephen Dummer, Monto Ho, David H. Van Thiel, Thomas E. Starzl, Shunzaburo Iwatsuki, Byers Wendell Shaw Jr

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after transplantation. In the first 8 weeks after transplantation, death occurred in 69% (18/26) of patients with fungal infection but in only 8% (3/36) of patients without fungal infection (P<0.0005). The cause of death, however, was usually multifactorial, and not solely due to the fungal infection. Fungal infections were associated with the following clinical factors: administration of preoperative steroids (P<0.05) and antibiotics (P<0.05), longer transplant operative time (P<0.02), longer posttransplant operative time (P<0.01), duration of antibiotic use after transplant surgery (P<0.001), and the number of steroid boluses administered to control rejection in the first 2 posttransplant months (P<0.01). Patients with primary biliary cirrhosis had fewer fungal infections than patients with other underlying liver diseases (P<0.05). A total of 41% (9/22) of Candida infections resolved, but all Aspergillus infections ended in death.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalTransplantation
Volume40
Issue number4
DOIs
StatePublished - Jan 1 1985

Fingerprint

Mycoses
Liver
Candida glabrata
Aspergillus
Operative Time
Transplantation
Steroids
Anti-Bacterial Agents
Transplants
Biliary Liver Cirrhosis
Infection
Transplant Recipients
Candida
Liver Transplantation
Liver Diseases
Cause of Death

ASJC Scopus subject areas

  • Transplantation

Cite this

Wajszczuk, C. P., Dummer, J. S., Ho, M., Van Thiel, D. H., Starzl, T. E., Iwatsuki, S., & Shaw Jr, B. W. (1985). Fungal infections in liver transplant recipients. Transplantation, 40(4), 347-353. https://doi.org/10.1097/00007890-198510000-00002

Fungal infections in liver transplant recipients. / Wajszczuk, Charles P.; Dummer, J. Stephen; Ho, Monto; Van Thiel, David H.; Starzl, Thomas E.; Iwatsuki, Shunzaburo; Shaw Jr, Byers Wendell.

In: Transplantation, Vol. 40, No. 4, 01.01.1985, p. 347-353.

Research output: Contribution to journalArticle

Wajszczuk, CP, Dummer, JS, Ho, M, Van Thiel, DH, Starzl, TE, Iwatsuki, S & Shaw Jr, BW 1985, 'Fungal infections in liver transplant recipients', Transplantation, vol. 40, no. 4, pp. 347-353. https://doi.org/10.1097/00007890-198510000-00002
Wajszczuk CP, Dummer JS, Ho M, Van Thiel DH, Starzl TE, Iwatsuki S et al. Fungal infections in liver transplant recipients. Transplantation. 1985 Jan 1;40(4):347-353. https://doi.org/10.1097/00007890-198510000-00002
Wajszczuk, Charles P. ; Dummer, J. Stephen ; Ho, Monto ; Van Thiel, David H. ; Starzl, Thomas E. ; Iwatsuki, Shunzaburo ; Shaw Jr, Byers Wendell. / Fungal infections in liver transplant recipients. In: Transplantation. 1985 ; Vol. 40, No. 4. pp. 347-353.
@article{e696791f00214fa29815e11410552d4a,
title = "Fungal infections in liver transplant recipients",
abstract = "Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after transplantation. In the first 8 weeks after transplantation, death occurred in 69{\%} (18/26) of patients with fungal infection but in only 8{\%} (3/36) of patients without fungal infection (P<0.0005). The cause of death, however, was usually multifactorial, and not solely due to the fungal infection. Fungal infections were associated with the following clinical factors: administration of preoperative steroids (P<0.05) and antibiotics (P<0.05), longer transplant operative time (P<0.02), longer posttransplant operative time (P<0.01), duration of antibiotic use after transplant surgery (P<0.001), and the number of steroid boluses administered to control rejection in the first 2 posttransplant months (P<0.01). Patients with primary biliary cirrhosis had fewer fungal infections than patients with other underlying liver diseases (P<0.05). A total of 41{\%} (9/22) of Candida infections resolved, but all Aspergillus infections ended in death.",
author = "Wajszczuk, {Charles P.} and Dummer, {J. Stephen} and Monto Ho and {Van Thiel}, {David H.} and Starzl, {Thomas E.} and Shunzaburo Iwatsuki and {Shaw Jr}, {Byers Wendell}",
year = "1985",
month = "1",
day = "1",
doi = "10.1097/00007890-198510000-00002",
language = "English (US)",
volume = "40",
pages = "347--353",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Fungal infections in liver transplant recipients

AU - Wajszczuk, Charles P.

AU - Dummer, J. Stephen

AU - Ho, Monto

AU - Van Thiel, David H.

AU - Starzl, Thomas E.

AU - Iwatsuki, Shunzaburo

AU - Shaw Jr, Byers Wendell

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after transplantation. In the first 8 weeks after transplantation, death occurred in 69% (18/26) of patients with fungal infection but in only 8% (3/36) of patients without fungal infection (P<0.0005). The cause of death, however, was usually multifactorial, and not solely due to the fungal infection. Fungal infections were associated with the following clinical factors: administration of preoperative steroids (P<0.05) and antibiotics (P<0.05), longer transplant operative time (P<0.02), longer posttransplant operative time (P<0.01), duration of antibiotic use after transplant surgery (P<0.001), and the number of steroid boluses administered to control rejection in the first 2 posttransplant months (P<0.01). Patients with primary biliary cirrhosis had fewer fungal infections than patients with other underlying liver diseases (P<0.05). A total of 41% (9/22) of Candida infections resolved, but all Aspergillus infections ended in death.

AB - Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after transplantation. In the first 8 weeks after transplantation, death occurred in 69% (18/26) of patients with fungal infection but in only 8% (3/36) of patients without fungal infection (P<0.0005). The cause of death, however, was usually multifactorial, and not solely due to the fungal infection. Fungal infections were associated with the following clinical factors: administration of preoperative steroids (P<0.05) and antibiotics (P<0.05), longer transplant operative time (P<0.02), longer posttransplant operative time (P<0.01), duration of antibiotic use after transplant surgery (P<0.001), and the number of steroid boluses administered to control rejection in the first 2 posttransplant months (P<0.01). Patients with primary biliary cirrhosis had fewer fungal infections than patients with other underlying liver diseases (P<0.05). A total of 41% (9/22) of Candida infections resolved, but all Aspergillus infections ended in death.

UR - http://www.scopus.com/inward/record.url?scp=0022361085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022361085&partnerID=8YFLogxK

U2 - 10.1097/00007890-198510000-00002

DO - 10.1097/00007890-198510000-00002

M3 - Article

VL - 40

SP - 347

EP - 353

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 4

ER -