Functions of GSK-3 signaling in development of the nervous system

Woo Yang Kim, William D. Snider

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development centered on the regulation of neuronal polarity using in vitro paradigms. However, recent creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development including neural progenitor self-renewal, neurogenesis, neuronal migration, neural differentiation, and synaptic development.

Original languageEnglish (US)
Article number44
JournalFrontiers in Molecular Neuroscience
Volume4
Issue numberNOV
DOIs
StatePublished - Nov 17 2011

    Fingerprint

Keywords

  • GSK-3
  • Neural progenitor
  • Neuronal migration

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this