Functions of GSK-3 signaling in development of the nervous system

Woo Yang Kim, William D. Snider

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development centered on the regulation of neuronal polarity using in vitro paradigms. However, recent creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development including neural progenitor self-renewal, neurogenesis, neuronal migration, neural differentiation, and synaptic development.

Original languageEnglish (US)
Article number44
JournalFrontiers in Molecular Neuroscience
Volume4
Issue numberNOV
DOIs
StatePublished - Nov 17 2011

Fingerprint

Glycogen Synthase Kinase 3
Nervous System
Catenins
Genetic Models
Neurogenesis
G-Protein-Coupled Receptors
Intercellular Signaling Peptides and Proteins

Keywords

  • GSK-3
  • Neural progenitor
  • Neuronal migration

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Functions of GSK-3 signaling in development of the nervous system. / Kim, Woo Yang; Snider, William D.

In: Frontiers in Molecular Neuroscience, Vol. 4, No. NOV, 44, 17.11.2011.

Research output: Contribution to journalReview article

Kim, Woo Yang ; Snider, William D. / Functions of GSK-3 signaling in development of the nervous system. In: Frontiers in Molecular Neuroscience. 2011 ; Vol. 4, No. NOV.
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