Abstract
Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 164-174 |
| Number of pages | 11 |
| Journal | Virology |
| Volume | 400 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1 2010 |
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Keywords
- Autologous or heterologous antibodies
- Envelope glycoproteins
- Envelope processing and incorporation
- HIV-1 subtype C
- Neutralization
- Perinatal transmission
ASJC Scopus subject areas
- Virology
Cite this
Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission. / Zhang, Hong; Rola, Marzena; West, John T; Tully, Damien C.; Kubis, Piotr; He, Jun; Kankasa, Chipepo; Wood, Charles.
In: Virology, Vol. 400, No. 2, 01.05.2010, p. 164-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission
AU - Zhang, Hong
AU - Rola, Marzena
AU - West, John T
AU - Tully, Damien C.
AU - Kubis, Piotr
AU - He, Jun
AU - Kankasa, Chipepo
AU - Wood, Charles
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches.
AB - Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the newly transmitted variants were sensitive to neutralization by pooled heterologous plasma but in general were resistant to IgG1 b12. Neither Env processing nor incorporation efficiency was predictive of viral transmissibility. These findings provide further insight into the characteristics of perinatally transmissible HIV-1 and may have implications for intervention approaches.
KW - Autologous or heterologous antibodies
KW - Envelope glycoproteins
KW - Envelope processing and incorporation
KW - HIV-1 subtype C
KW - Neutralization
KW - Perinatal transmission
UR - http://www.scopus.com/inward/record.url?scp=77949571338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949571338&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2009.12.019
DO - 10.1016/j.virol.2009.12.019
M3 - Article
C2 - 20096914
AN - SCOPUS:77949571338
VL - 400
SP - 164
EP - 174
JO - Virology
JF - Virology
SN - 0042-6822
IS - 2
ER -