Functional maturation of left and right atrial systolic and diastolic performance in infants, children, and adolescents

Shelby Kutty, Asif Padiyath, Ling Li, Qinghai Peng, Sheela Rangamani, Andreas Schuster, David Alan Danford

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Left atrial (LA) function is an important modulator of left ventricular filling and has a prognostic role in adult heart failure, but pediatric data are limited. The aim of this study was to characterize the normal LA and right atrial (RA) strain (ε) and strain rate (SR) in infants and children. Methods: Atrial ε and SR were prospectively investigated in 153 subjects using two-dimensional speckle-tracking echocardiography. High-frame rate, three-beat captures of LA (15-segment model; two-chamber, three-chamber, and four-chamber views) and RA (six-segment model; four-chamber view) were analyzed (Vivid 7, EchoPAC BT11). LA and RA segmental and global peak positive ε (εPos) and negative ε (εNeg) and peak positive SR, early negative SR, and late negative SR were measured. Linear and nonlinear regressions of ε and SR were performed with age and heart rate. Relationships of ε and SR with ventricular inflow Doppler and myocardial tissue Doppler indices were explored. Results: The age range was 3 days to 20 years, and body surface area range from 0.17 to 2.3 m2 for the study cohort. Mean global LA εPos, LA εNeg, RA εPos, and RA εNeg were 28 ± 9%, -16 ± 6%, 23 ± 9%, and -15 ± 6%, respectively. Positive correlations were found for global atrial εPos and εNeg with age (P <.001). A marked rate of changes in ε and SR was seen in the first year of life, reaching normal adult values by adolescence. Peak positive SR had a strong negative correlation with age, and early negative SR had a strong positive correlation with age (P <.001), while late negative SR was correlated nonlinearly. Heart rate and age both influenced all LA and RA ε and SR indices. Conclusions: Maturational changes in LA and RA ε and SR occur in normal children and are especially profound in infancy. Consequently, LA and RA performance indices must be interpreted in light of heart rate and age. Normal values and percentiles for atrial ε and SR reported here will provide a foundation for the study of pediatric atrial physiology and function in disease states.

Original languageEnglish (US)
Pages (from-to)398-409.e2
JournalJournal of the American Society of Echocardiography
Volume26
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Heart Rate
Reference Values
Atrial Function
Left Atrial Function
Pediatrics
Body Surface Area
Echocardiography
Linear Models
Cohort Studies
Heart Failure

Keywords

  • Atrial function
  • Atrial strain
  • Atrial strain rate
  • Pediatric cardiology
  • Two-dimensional speckle-tracking

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Functional maturation of left and right atrial systolic and diastolic performance in infants, children, and adolescents. / Kutty, Shelby; Padiyath, Asif; Li, Ling; Peng, Qinghai; Rangamani, Sheela; Schuster, Andreas; Danford, David Alan.

In: Journal of the American Society of Echocardiography, Vol. 26, No. 4, 04.2013, p. 398-409.e2.

Research output: Contribution to journalArticle

@article{8e41bfddfeb74e18b3cdbe301f5b6f66,
title = "Functional maturation of left and right atrial systolic and diastolic performance in infants, children, and adolescents",
abstract = "Background: Left atrial (LA) function is an important modulator of left ventricular filling and has a prognostic role in adult heart failure, but pediatric data are limited. The aim of this study was to characterize the normal LA and right atrial (RA) strain (ε) and strain rate (SR) in infants and children. Methods: Atrial ε and SR were prospectively investigated in 153 subjects using two-dimensional speckle-tracking echocardiography. High-frame rate, three-beat captures of LA (15-segment model; two-chamber, three-chamber, and four-chamber views) and RA (six-segment model; four-chamber view) were analyzed (Vivid 7, EchoPAC BT11). LA and RA segmental and global peak positive ε (εPos) and negative ε (εNeg) and peak positive SR, early negative SR, and late negative SR were measured. Linear and nonlinear regressions of ε and SR were performed with age and heart rate. Relationships of ε and SR with ventricular inflow Doppler and myocardial tissue Doppler indices were explored. Results: The age range was 3 days to 20 years, and body surface area range from 0.17 to 2.3 m2 for the study cohort. Mean global LA εPos, LA εNeg, RA εPos, and RA εNeg were 28 ± 9{\%}, -16 ± 6{\%}, 23 ± 9{\%}, and -15 ± 6{\%}, respectively. Positive correlations were found for global atrial εPos and εNeg with age (P <.001). A marked rate of changes in ε and SR was seen in the first year of life, reaching normal adult values by adolescence. Peak positive SR had a strong negative correlation with age, and early negative SR had a strong positive correlation with age (P <.001), while late negative SR was correlated nonlinearly. Heart rate and age both influenced all LA and RA ε and SR indices. Conclusions: Maturational changes in LA and RA ε and SR occur in normal children and are especially profound in infancy. Consequently, LA and RA performance indices must be interpreted in light of heart rate and age. Normal values and percentiles for atrial ε and SR reported here will provide a foundation for the study of pediatric atrial physiology and function in disease states.",
keywords = "Atrial function, Atrial strain, Atrial strain rate, Pediatric cardiology, Two-dimensional speckle-tracking",
author = "Shelby Kutty and Asif Padiyath and Ling Li and Qinghai Peng and Sheela Rangamani and Andreas Schuster and Danford, {David Alan}",
year = "2013",
month = "4",
doi = "10.1016/j.echo.2012.12.016",
language = "English (US)",
volume = "26",
pages = "398--409.e2",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Functional maturation of left and right atrial systolic and diastolic performance in infants, children, and adolescents

AU - Kutty, Shelby

AU - Padiyath, Asif

AU - Li, Ling

AU - Peng, Qinghai

AU - Rangamani, Sheela

AU - Schuster, Andreas

AU - Danford, David Alan

PY - 2013/4

Y1 - 2013/4

N2 - Background: Left atrial (LA) function is an important modulator of left ventricular filling and has a prognostic role in adult heart failure, but pediatric data are limited. The aim of this study was to characterize the normal LA and right atrial (RA) strain (ε) and strain rate (SR) in infants and children. Methods: Atrial ε and SR were prospectively investigated in 153 subjects using two-dimensional speckle-tracking echocardiography. High-frame rate, three-beat captures of LA (15-segment model; two-chamber, three-chamber, and four-chamber views) and RA (six-segment model; four-chamber view) were analyzed (Vivid 7, EchoPAC BT11). LA and RA segmental and global peak positive ε (εPos) and negative ε (εNeg) and peak positive SR, early negative SR, and late negative SR were measured. Linear and nonlinear regressions of ε and SR were performed with age and heart rate. Relationships of ε and SR with ventricular inflow Doppler and myocardial tissue Doppler indices were explored. Results: The age range was 3 days to 20 years, and body surface area range from 0.17 to 2.3 m2 for the study cohort. Mean global LA εPos, LA εNeg, RA εPos, and RA εNeg were 28 ± 9%, -16 ± 6%, 23 ± 9%, and -15 ± 6%, respectively. Positive correlations were found for global atrial εPos and εNeg with age (P <.001). A marked rate of changes in ε and SR was seen in the first year of life, reaching normal adult values by adolescence. Peak positive SR had a strong negative correlation with age, and early negative SR had a strong positive correlation with age (P <.001), while late negative SR was correlated nonlinearly. Heart rate and age both influenced all LA and RA ε and SR indices. Conclusions: Maturational changes in LA and RA ε and SR occur in normal children and are especially profound in infancy. Consequently, LA and RA performance indices must be interpreted in light of heart rate and age. Normal values and percentiles for atrial ε and SR reported here will provide a foundation for the study of pediatric atrial physiology and function in disease states.

AB - Background: Left atrial (LA) function is an important modulator of left ventricular filling and has a prognostic role in adult heart failure, but pediatric data are limited. The aim of this study was to characterize the normal LA and right atrial (RA) strain (ε) and strain rate (SR) in infants and children. Methods: Atrial ε and SR were prospectively investigated in 153 subjects using two-dimensional speckle-tracking echocardiography. High-frame rate, three-beat captures of LA (15-segment model; two-chamber, three-chamber, and four-chamber views) and RA (six-segment model; four-chamber view) were analyzed (Vivid 7, EchoPAC BT11). LA and RA segmental and global peak positive ε (εPos) and negative ε (εNeg) and peak positive SR, early negative SR, and late negative SR were measured. Linear and nonlinear regressions of ε and SR were performed with age and heart rate. Relationships of ε and SR with ventricular inflow Doppler and myocardial tissue Doppler indices were explored. Results: The age range was 3 days to 20 years, and body surface area range from 0.17 to 2.3 m2 for the study cohort. Mean global LA εPos, LA εNeg, RA εPos, and RA εNeg were 28 ± 9%, -16 ± 6%, 23 ± 9%, and -15 ± 6%, respectively. Positive correlations were found for global atrial εPos and εNeg with age (P <.001). A marked rate of changes in ε and SR was seen in the first year of life, reaching normal adult values by adolescence. Peak positive SR had a strong negative correlation with age, and early negative SR had a strong positive correlation with age (P <.001), while late negative SR was correlated nonlinearly. Heart rate and age both influenced all LA and RA ε and SR indices. Conclusions: Maturational changes in LA and RA ε and SR occur in normal children and are especially profound in infancy. Consequently, LA and RA performance indices must be interpreted in light of heart rate and age. Normal values and percentiles for atrial ε and SR reported here will provide a foundation for the study of pediatric atrial physiology and function in disease states.

KW - Atrial function

KW - Atrial strain

KW - Atrial strain rate

KW - Pediatric cardiology

KW - Two-dimensional speckle-tracking

UR - http://www.scopus.com/inward/record.url?scp=84875520303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875520303&partnerID=8YFLogxK

U2 - 10.1016/j.echo.2012.12.016

DO - 10.1016/j.echo.2012.12.016

M3 - Article

C2 - 23337737

AN - SCOPUS:84875520303

VL - 26

SP - 398-409.e2

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 4

ER -