Functional brain abnormalities during finger-tapping in HIV-infected older adults: A magnetoencephalography study

Tony W Wilson, Elizabeth C Heinrichs-Graham, Kevin R. Robertson, Uriel Sandkovsky, Jennifer O'Neill, Nichole L. Knott, Howard S Fox, Susan Swindells

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Despite the availability of combination antiretroviral therapy, at least mild cognitive dysfunction is commonly observed in HIV-infected patients, with an estimated prevalence of 35-70 %. Neuropsychological studies of these HIV-associated neurocognitive disorders (HAND) have documented aberrations across a broad range of functional domains, although the basic pathophysiology remains unresolved. Some of the most common findings have been deficits in fine motor control and reduced psychomotor speed, but to date no neuroimaging studies have evaluated basic motor control in HAND. In this study, we used magnetoencephalography (MEG) to evaluate the neurophysiological processes that underlie motor planning in older HIV-infected adults and a matched, uninfected control group. MEG is a noninvasive and direct measure of neural activity with good spatiotemporal precision. During the MEG recording, participants fixated on a central crosshair and performed a finger-tapping task with the dominant hand. All MEG data was corrected for head movements, preprocessed, and imaged in the time-frequency domain using beamforming methodology. All analyses focused on the pre-movement beta desynchronization, which is known to be an index of movement planning. Our results demonstrated that HIV-1-infected patients have deficient beta desynchronization relative to controls within the left/right precentral gyri, and the supplementary motor area. In contrast, HIV-infected persons showed abnormally strong beta responses compared to controls in the right dorsolateral prefrontal cortex and medial prefrontal areas. In addition, the amplitude of beta activity in the primary and supplementary motor areas correlated with scores on the Grooved Pegboard test in HIV-infected adults. These results demonstrate that primary motor and sensory regions may be particularly vulnerable to HIV-associated damage, and that prefrontal cortices may serve a compensatory role in maintaining motor performance levels in infected patients.

Original languageEnglish (US)
Pages (from-to)965-974
Number of pages10
JournalJournal of Neuroimmune Pharmacology
Volume8
Issue number4
DOIs
StatePublished - Sep 1 2013

Fingerprint

Magnetoencephalography
Fingers
HIV
Brain
Motor Cortex
Prefrontal Cortex
Head Movements
Frontal Lobe
Neuroimaging
HIV-1
Hand
Control Groups

Keywords

  • AIDS
  • Biomarker
  • Cognitive disorders
  • HAND
  • MEG
  • beta ERD

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Functional brain abnormalities during finger-tapping in HIV-infected older adults : A magnetoencephalography study. / Wilson, Tony W; Heinrichs-Graham, Elizabeth C; Robertson, Kevin R.; Sandkovsky, Uriel; O'Neill, Jennifer; Knott, Nichole L.; Fox, Howard S; Swindells, Susan.

In: Journal of Neuroimmune Pharmacology, Vol. 8, No. 4, 01.09.2013, p. 965-974.

Research output: Contribution to journalArticle

@article{2a91b6ecc1ec4e69affa190aad9019e9,
title = "Functional brain abnormalities during finger-tapping in HIV-infected older adults: A magnetoencephalography study",
abstract = "Despite the availability of combination antiretroviral therapy, at least mild cognitive dysfunction is commonly observed in HIV-infected patients, with an estimated prevalence of 35-70 {\%}. Neuropsychological studies of these HIV-associated neurocognitive disorders (HAND) have documented aberrations across a broad range of functional domains, although the basic pathophysiology remains unresolved. Some of the most common findings have been deficits in fine motor control and reduced psychomotor speed, but to date no neuroimaging studies have evaluated basic motor control in HAND. In this study, we used magnetoencephalography (MEG) to evaluate the neurophysiological processes that underlie motor planning in older HIV-infected adults and a matched, uninfected control group. MEG is a noninvasive and direct measure of neural activity with good spatiotemporal precision. During the MEG recording, participants fixated on a central crosshair and performed a finger-tapping task with the dominant hand. All MEG data was corrected for head movements, preprocessed, and imaged in the time-frequency domain using beamforming methodology. All analyses focused on the pre-movement beta desynchronization, which is known to be an index of movement planning. Our results demonstrated that HIV-1-infected patients have deficient beta desynchronization relative to controls within the left/right precentral gyri, and the supplementary motor area. In contrast, HIV-infected persons showed abnormally strong beta responses compared to controls in the right dorsolateral prefrontal cortex and medial prefrontal areas. In addition, the amplitude of beta activity in the primary and supplementary motor areas correlated with scores on the Grooved Pegboard test in HIV-infected adults. These results demonstrate that primary motor and sensory regions may be particularly vulnerable to HIV-associated damage, and that prefrontal cortices may serve a compensatory role in maintaining motor performance levels in infected patients.",
keywords = "AIDS, Biomarker, Cognitive disorders, HAND, MEG, beta ERD",
author = "Wilson, {Tony W} and Heinrichs-Graham, {Elizabeth C} and Robertson, {Kevin R.} and Uriel Sandkovsky and Jennifer O'Neill and Knott, {Nichole L.} and Fox, {Howard S} and Susan Swindells",
year = "2013",
month = "9",
day = "1",
doi = "10.1007/s11481-013-9477-1",
language = "English (US)",
volume = "8",
pages = "965--974",
journal = "Journal of NeuroImmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Functional brain abnormalities during finger-tapping in HIV-infected older adults

T2 - A magnetoencephalography study

AU - Wilson, Tony W

AU - Heinrichs-Graham, Elizabeth C

AU - Robertson, Kevin R.

AU - Sandkovsky, Uriel

AU - O'Neill, Jennifer

AU - Knott, Nichole L.

AU - Fox, Howard S

AU - Swindells, Susan

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Despite the availability of combination antiretroviral therapy, at least mild cognitive dysfunction is commonly observed in HIV-infected patients, with an estimated prevalence of 35-70 %. Neuropsychological studies of these HIV-associated neurocognitive disorders (HAND) have documented aberrations across a broad range of functional domains, although the basic pathophysiology remains unresolved. Some of the most common findings have been deficits in fine motor control and reduced psychomotor speed, but to date no neuroimaging studies have evaluated basic motor control in HAND. In this study, we used magnetoencephalography (MEG) to evaluate the neurophysiological processes that underlie motor planning in older HIV-infected adults and a matched, uninfected control group. MEG is a noninvasive and direct measure of neural activity with good spatiotemporal precision. During the MEG recording, participants fixated on a central crosshair and performed a finger-tapping task with the dominant hand. All MEG data was corrected for head movements, preprocessed, and imaged in the time-frequency domain using beamforming methodology. All analyses focused on the pre-movement beta desynchronization, which is known to be an index of movement planning. Our results demonstrated that HIV-1-infected patients have deficient beta desynchronization relative to controls within the left/right precentral gyri, and the supplementary motor area. In contrast, HIV-infected persons showed abnormally strong beta responses compared to controls in the right dorsolateral prefrontal cortex and medial prefrontal areas. In addition, the amplitude of beta activity in the primary and supplementary motor areas correlated with scores on the Grooved Pegboard test in HIV-infected adults. These results demonstrate that primary motor and sensory regions may be particularly vulnerable to HIV-associated damage, and that prefrontal cortices may serve a compensatory role in maintaining motor performance levels in infected patients.

AB - Despite the availability of combination antiretroviral therapy, at least mild cognitive dysfunction is commonly observed in HIV-infected patients, with an estimated prevalence of 35-70 %. Neuropsychological studies of these HIV-associated neurocognitive disorders (HAND) have documented aberrations across a broad range of functional domains, although the basic pathophysiology remains unresolved. Some of the most common findings have been deficits in fine motor control and reduced psychomotor speed, but to date no neuroimaging studies have evaluated basic motor control in HAND. In this study, we used magnetoencephalography (MEG) to evaluate the neurophysiological processes that underlie motor planning in older HIV-infected adults and a matched, uninfected control group. MEG is a noninvasive and direct measure of neural activity with good spatiotemporal precision. During the MEG recording, participants fixated on a central crosshair and performed a finger-tapping task with the dominant hand. All MEG data was corrected for head movements, preprocessed, and imaged in the time-frequency domain using beamforming methodology. All analyses focused on the pre-movement beta desynchronization, which is known to be an index of movement planning. Our results demonstrated that HIV-1-infected patients have deficient beta desynchronization relative to controls within the left/right precentral gyri, and the supplementary motor area. In contrast, HIV-infected persons showed abnormally strong beta responses compared to controls in the right dorsolateral prefrontal cortex and medial prefrontal areas. In addition, the amplitude of beta activity in the primary and supplementary motor areas correlated with scores on the Grooved Pegboard test in HIV-infected adults. These results demonstrate that primary motor and sensory regions may be particularly vulnerable to HIV-associated damage, and that prefrontal cortices may serve a compensatory role in maintaining motor performance levels in infected patients.

KW - AIDS

KW - Biomarker

KW - Cognitive disorders

KW - HAND

KW - MEG

KW - beta ERD

UR - http://www.scopus.com/inward/record.url?scp=84882277745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882277745&partnerID=8YFLogxK

U2 - 10.1007/s11481-013-9477-1

DO - 10.1007/s11481-013-9477-1

M3 - Article

C2 - 23749418

AN - SCOPUS:84882277745

VL - 8

SP - 965

EP - 974

JO - Journal of NeuroImmune Pharmacology

JF - Journal of NeuroImmune Pharmacology

SN - 1557-1890

IS - 4

ER -