Fulminant hepatic failure and orthotopic liver transplantation

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58%. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100%, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalSeminars in liver disease
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1989

Fingerprint

Acute Liver Failure
Liver Transplantation
Survival
Transplantation
Hepatolenticular Degeneration
Brain Edema
Acute Disease
Acetaminophen
Referral and Consultation
Transplants
Mortality
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Fulminant hepatic failure and orthotopic liver transplantation. / Schafer, Daniel Francis; Shaw, B. W.

In: Seminars in liver disease, Vol. 9, No. 3, 01.01.1989, p. 189-194.

Research output: Contribution to journalReview article

@article{ac96df0f45ee4f9d9c5578ec43f68d50,
title = "Fulminant hepatic failure and orthotopic liver transplantation",
abstract = "Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58{\%}. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100{\%}, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.",
author = "Schafer, {Daniel Francis} and Shaw, {B. W.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1055/s-2008-1040512",
language = "English (US)",
volume = "9",
pages = "189--194",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "3",

}

TY - JOUR

T1 - Fulminant hepatic failure and orthotopic liver transplantation

AU - Schafer, Daniel Francis

AU - Shaw, B. W.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58%. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100%, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.

AB - Twenty-four patients were transplanted for fulminant hepatic failure at the University of Nebraska Medical Center from 1986 (July) to 1988. Long-term survival is about 58%. FHF is an increasingly common indication for liver transplantation. Cerebral edema, organ availability, and late referral are obstacles to improved survival. Randomized trials have not been performed to demonstrate that transplantation is superior toother therapies. For some etiologies, such as acute Wilson's disease, in which mortality is 100%, transplantation is clearly indicated. For other etiologies, such as acetaminophen-induced FHF, in which clear gains in survival have been shown using more conservative therapies, the decision to transplant patients becomes more difficult. As all forms of therapy improve, all patients will benefit.

UR - http://www.scopus.com/inward/record.url?scp=0024446468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024446468&partnerID=8YFLogxK

U2 - 10.1055/s-2008-1040512

DO - 10.1055/s-2008-1040512

M3 - Review article

C2 - 2683105

AN - SCOPUS:0024446468

VL - 9

SP - 189

EP - 194

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 3

ER -