Fulminant Clostridium difficile colitis

Sasha D. Adams, David W. Mercer

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Clostridium difficile is the most common cause of nosocomial infectious diarrhea in adults. The purpose of this review is to increase awareness that infection from C. difficile is not always indolent, but with fulminant colitis, it can be lethal. The epidemiology, pathogenesis and treatment of C. difficile infection are discussed, with special emphasis on management of fulminant colitis. RECENT FINDINGS: Clostridium difficile causes fulminant colitis in 3-8% of patients. Early predictors of disease include immunosuppression, hypotension, hypoalbuminemia, and a pronounced leukocytosis. In patients with fulminant colitis, early colectomy before vasopressor therapy is required and may improve survival. SUMMARY: The incidence and virulence of C. difficile infection are increasing. Antibiotic use and length of hospital stay correlate strongly with infection. Oral or intravenous metronidazole is the recommended first-line therapy, with discontinuation of systemic antibiotics if possible. Forty percent of patients may have a prolonged course and 20% will relapse despite adequate therapy. Fulminant colitis develops in 3-8% of patients; diagnosis can be difficult with diarrhea absent in 20% of the subgroup. Once diagnosed, subtotal colectomy with ileostomy is usually required. In patients with a marked leukocytosis or bandemia, surgery is advisable because the leukocytosis frequently precedes hypotension and the requirement for vasopressor therapy, which carries a poor prognosis.

Original languageEnglish (US)
Pages (from-to)450-455
Number of pages6
JournalCurrent Opinion in Critical Care
Volume13
Issue number4
DOIs
StatePublished - Aug 1 2007

Fingerprint

Clostridium difficile
Colitis
Leukocytosis
Clostridium Infections
Colectomy
Hypotension
Diarrhea
Length of Stay
Anti-Bacterial Agents
Therapeutics
Hypoalbuminemia
Ileostomy
Metronidazole
Infection
Immunosuppression
Virulence
Epidemiology
Recurrence
Survival
Incidence

Keywords

  • Antibiotics
  • Clostridium difficile
  • Fulminant colitis
  • Pseudomembranous colitis
  • Surgery

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Fulminant Clostridium difficile colitis. / Adams, Sasha D.; Mercer, David W.

In: Current Opinion in Critical Care, Vol. 13, No. 4, 01.08.2007, p. 450-455.

Research output: Contribution to journalReview article

Adams, Sasha D. ; Mercer, David W. / Fulminant Clostridium difficile colitis. In: Current Opinion in Critical Care. 2007 ; Vol. 13, No. 4. pp. 450-455.
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