Fruit and vegetable consumption is inversely associated with having pancreatic cancer

Rick J Jansen, Dennis P. Robinson, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Mariza De Andrade, Ann L. Oberg, Traci J. Hammer, Kari G. Rabe, Kristin E. Anderson, Janet E. Olson, Rashmi Sinha, Gloria M. Petersen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship. Methods: Participants were excluded who reported changing their diet within 5 years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5 years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption. Results: Comparing highest to lowest quintiles, we observed significant inverse associations (OR < 0.8) with significant trends (p trend < 0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake. Conclusions: We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies.

Original languageEnglish (US)
Pages (from-to)1613-1625
Number of pages13
JournalCancer Causes and Control
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

Pancreatic Neoplasms
Vegetables
Fruit
Case-Control Studies
Odds Ratio
Citrus paradisi
Cucurbitaceae
Citrus
Peas
Lycopersicon esculentum
Energy Intake
Alcohol Drinking
Body Mass Index
Logistic Models
Smoking
Confidence Intervals
Diet
Food
Surveys and Questionnaires
Whole Grains

Keywords

  • Diet
  • Pancreatic cancer
  • Questionnaire
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jansen, R. J., Robinson, D. P., Stolzenberg-Solomon, R. Z., Bamlet, W. R., De Andrade, M., Oberg, A. L., ... Petersen, G. M. (2011). Fruit and vegetable consumption is inversely associated with having pancreatic cancer. Cancer Causes and Control, 22(12), 1613-1625. https://doi.org/10.1007/s10552-011-9838-0

Fruit and vegetable consumption is inversely associated with having pancreatic cancer. / Jansen, Rick J; Robinson, Dennis P.; Stolzenberg-Solomon, Rachael Z.; Bamlet, William R.; De Andrade, Mariza; Oberg, Ann L.; Hammer, Traci J.; Rabe, Kari G.; Anderson, Kristin E.; Olson, Janet E.; Sinha, Rashmi; Petersen, Gloria M.

In: Cancer Causes and Control, Vol. 22, No. 12, 01.12.2011, p. 1613-1625.

Research output: Contribution to journalArticle

Jansen, RJ, Robinson, DP, Stolzenberg-Solomon, RZ, Bamlet, WR, De Andrade, M, Oberg, AL, Hammer, TJ, Rabe, KG, Anderson, KE, Olson, JE, Sinha, R & Petersen, GM 2011, 'Fruit and vegetable consumption is inversely associated with having pancreatic cancer', Cancer Causes and Control, vol. 22, no. 12, pp. 1613-1625. https://doi.org/10.1007/s10552-011-9838-0
Jansen RJ, Robinson DP, Stolzenberg-Solomon RZ, Bamlet WR, De Andrade M, Oberg AL et al. Fruit and vegetable consumption is inversely associated with having pancreatic cancer. Cancer Causes and Control. 2011 Dec 1;22(12):1613-1625. https://doi.org/10.1007/s10552-011-9838-0
Jansen, Rick J ; Robinson, Dennis P. ; Stolzenberg-Solomon, Rachael Z. ; Bamlet, William R. ; De Andrade, Mariza ; Oberg, Ann L. ; Hammer, Traci J. ; Rabe, Kari G. ; Anderson, Kristin E. ; Olson, Janet E. ; Sinha, Rashmi ; Petersen, Gloria M. / Fruit and vegetable consumption is inversely associated with having pancreatic cancer. In: Cancer Causes and Control. 2011 ; Vol. 22, No. 12. pp. 1613-1625.
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