Abstract
Objective: Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship. Methods: Participants were excluded who reported changing their diet within 5 years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5 years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption. Results: Comparing highest to lowest quintiles, we observed significant inverse associations (OR < 0.8) with significant trends (p trend < 0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake. Conclusions: We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1613-1625 |
| Number of pages | 13 |
| Journal | Cancer Causes and Control |
| Volume | 22 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2011 |
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Keywords
- Diet
- Pancreatic cancer
- Questionnaire
- Risk
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Fruit and vegetable consumption is inversely associated with having pancreatic cancer. / Jansen, Rick J; Robinson, Dennis P.; Stolzenberg-Solomon, Rachael Z.; Bamlet, William R.; De Andrade, Mariza; Oberg, Ann L.; Hammer, Traci J.; Rabe, Kari G.; Anderson, Kristin E.; Olson, Janet E.; Sinha, Rashmi; Petersen, Gloria M.
In: Cancer Causes and Control, Vol. 22, No. 12, 01.12.2011, p. 1613-1625.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fruit and vegetable consumption is inversely associated with having pancreatic cancer
AU - Jansen, Rick J
AU - Robinson, Dennis P.
AU - Stolzenberg-Solomon, Rachael Z.
AU - Bamlet, William R.
AU - De Andrade, Mariza
AU - Oberg, Ann L.
AU - Hammer, Traci J.
AU - Rabe, Kari G.
AU - Anderson, Kristin E.
AU - Olson, Janet E.
AU - Sinha, Rashmi
AU - Petersen, Gloria M.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Objective: Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship. Methods: Participants were excluded who reported changing their diet within 5 years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5 years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption. Results: Comparing highest to lowest quintiles, we observed significant inverse associations (OR < 0.8) with significant trends (p trend < 0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake. Conclusions: We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies.
AB - Objective: Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship. Methods: Participants were excluded who reported changing their diet within 5 years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5 years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption. Results: Comparing highest to lowest quintiles, we observed significant inverse associations (OR < 0.8) with significant trends (p trend < 0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake. Conclusions: We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies.
KW - Diet
KW - Pancreatic cancer
KW - Questionnaire
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=82955161686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955161686&partnerID=8YFLogxK
U2 - 10.1007/s10552-011-9838-0
DO - 10.1007/s10552-011-9838-0
M3 - Article
VL - 22
SP - 1613
EP - 1625
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 12
ER -