Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy

Jing Xiang, Yang Liu, Yingying Wang, Elijah G. Kirtman, Rupesh Kotecha, Yangmei Chen, Xiaolin Huo, Hisako Fujiwara, Nat Hemasilpin, Ki Lee, Francesco T. Mangano, James Leach, Blaise Jones, Ton DeGrauw, Douglas Rose

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Purpose. Invasive intracranial recordings have suggested that high-frequency oscillation is involved in epileptogenesis and is highly localized to epileptogenic zones. The aim of the present study is to characterize the frequency and spatial patterns of high-frequency brain signals in childhood epilepsy using a non-invasive technology. Methods. Thirty children with clinically diagnosed epilepsy were studied using a whole head magnetoencephalography (MEG) system. MEG data were digitized at 4 000 Hz. The frequency and spatial characteristics of high-frequency neuromagnetic signals were analyzed using continuous wavelet transform and beamformer. Three-dimensional magnetic resonance imaging (MRI) was obtained for each patient to localize magnetic sources. Results. Twenty-six patients showed high-frequency (100-1 000 Hz) components (26/30, 86%). Nineteen patients showed more than one high-frequency component (19/30, 63%). The frequency range of high-frequency components varied across patients. The highest frequency band was identified around 910 Hz. The loci of high-frequency epileptic activities were concordant with the lesions identified by magnetic resonance imaging for 21 patients (21/30, 70%). The MEG source localizations of high-frequency components were found to be concordant with intracranial recordings for nine of the eleven patients who underwent epilepsy surgery (9/11, 82%). Conclusion. The results have demonstrated that childhood epilepsy was associated with high-frequency epileptic activity in a wide frequency range. The concordance of MEG source localization, MRI and intracranial recordings suggests that measurement of high-frequency neuromagnetic signals might provide a novel approach for clinical management of childhood epilepsy.

Original languageEnglish (US)
Pages (from-to)113-125
Number of pages13
JournalEpileptic Disorders
Volume11
Issue number2
DOIs
StatePublished - Jun 1 2009

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Magnetoencephalography
Epilepsy
Magnetic Resonance Imaging
Wavelet Analysis
Head
Technology
Brain

Keywords

  • Beamformer
  • Children
  • Epilepsy
  • High-frequency oscillation
  • Magnetoencephalography
  • Wavelet

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. / Xiang, Jing; Liu, Yang; Wang, Yingying; Kirtman, Elijah G.; Kotecha, Rupesh; Chen, Yangmei; Huo, Xiaolin; Fujiwara, Hisako; Hemasilpin, Nat; Lee, Ki; Mangano, Francesco T.; Leach, James; Jones, Blaise; DeGrauw, Ton; Rose, Douglas.

In: Epileptic Disorders, Vol. 11, No. 2, 01.06.2009, p. 113-125.

Research output: Contribution to journalArticle

Xiang, J, Liu, Y, Wang, Y, Kirtman, EG, Kotecha, R, Chen, Y, Huo, X, Fujiwara, H, Hemasilpin, N, Lee, K, Mangano, FT, Leach, J, Jones, B, DeGrauw, T & Rose, D 2009, 'Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy', Epileptic Disorders, vol. 11, no. 2, pp. 113-125. https://doi.org/10.1684/epd.2009.0253
Xiang, Jing ; Liu, Yang ; Wang, Yingying ; Kirtman, Elijah G. ; Kotecha, Rupesh ; Chen, Yangmei ; Huo, Xiaolin ; Fujiwara, Hisako ; Hemasilpin, Nat ; Lee, Ki ; Mangano, Francesco T. ; Leach, James ; Jones, Blaise ; DeGrauw, Ton ; Rose, Douglas. / Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. In: Epileptic Disorders. 2009 ; Vol. 11, No. 2. pp. 113-125.
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abstract = "Purpose. Invasive intracranial recordings have suggested that high-frequency oscillation is involved in epileptogenesis and is highly localized to epileptogenic zones. The aim of the present study is to characterize the frequency and spatial patterns of high-frequency brain signals in childhood epilepsy using a non-invasive technology. Methods. Thirty children with clinically diagnosed epilepsy were studied using a whole head magnetoencephalography (MEG) system. MEG data were digitized at 4 000 Hz. The frequency and spatial characteristics of high-frequency neuromagnetic signals were analyzed using continuous wavelet transform and beamformer. Three-dimensional magnetic resonance imaging (MRI) was obtained for each patient to localize magnetic sources. Results. Twenty-six patients showed high-frequency (100-1 000 Hz) components (26/30, 86{\%}). Nineteen patients showed more than one high-frequency component (19/30, 63{\%}). The frequency range of high-frequency components varied across patients. The highest frequency band was identified around 910 Hz. The loci of high-frequency epileptic activities were concordant with the lesions identified by magnetic resonance imaging for 21 patients (21/30, 70{\%}). The MEG source localizations of high-frequency components were found to be concordant with intracranial recordings for nine of the eleven patients who underwent epilepsy surgery (9/11, 82{\%}). Conclusion. The results have demonstrated that childhood epilepsy was associated with high-frequency epileptic activity in a wide frequency range. The concordance of MEG source localization, MRI and intracranial recordings suggests that measurement of high-frequency neuromagnetic signals might provide a novel approach for clinical management of childhood epilepsy.",
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AU - Chen, Yangmei

AU - Huo, Xiaolin

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AU - Hemasilpin, Nat

AU - Lee, Ki

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AU - Leach, James

AU - Jones, Blaise

AU - DeGrauw, Ton

AU - Rose, Douglas

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