Free radicals and phagocytic cells

G. M. Rosen, S. Pou, C. L. Ramos, M. S. Cohen, B. E. Britigan

Research output: Contribution to journalReview article

382 Citations (Scopus)

Abstract

Phagocytes mediate their innate immunological response by releasing products that damage invading microorganisms. These products include proteins such as lysozyme, peroxidases, and elastase as well as reactive oxygen species such as superoxide, hydrogen peroxide, hypohalous acid, and hydroxyl radical. Although it is dear that many phagocytic secretory products have direct cytotoxic potential, understanding is limited of how multiple products interact to generate and modulate the cytotoxic response. This review focuses on recent findings that elucidate the biochemical nature of secretory product interaction in the formation of free radicals, particularly the highly reactive hydroxyl radical. The possible role of these reactions in phagocyte microbicidal activity and inflammatory tissue injury is discussed.

Original languageEnglish (US)
Pages (from-to)200-209
Number of pages10
JournalFASEB Journal
Volume9
Issue number2
StatePublished - Jan 1 1995

Fingerprint

phagocytes
hydroxyl radicals
Phagocytes
Hydroxyl Radical
Free Radicals
Peroxidases
elastase
Pancreatic Elastase
peroxidases
protein products
Muramidase
lysozyme
Superoxides
Microorganisms
superoxide anion
Hydrogen Peroxide
hydrogen peroxide
reactive oxygen species
Reactive Oxygen Species
immune response

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Rosen, G. M., Pou, S., Ramos, C. L., Cohen, M. S., & Britigan, B. E. (1995). Free radicals and phagocytic cells. FASEB Journal, 9(2), 200-209.

Free radicals and phagocytic cells. / Rosen, G. M.; Pou, S.; Ramos, C. L.; Cohen, M. S.; Britigan, B. E.

In: FASEB Journal, Vol. 9, No. 2, 01.01.1995, p. 200-209.

Research output: Contribution to journalReview article

Rosen, GM, Pou, S, Ramos, CL, Cohen, MS & Britigan, BE 1995, 'Free radicals and phagocytic cells', FASEB Journal, vol. 9, no. 2, pp. 200-209.
Rosen GM, Pou S, Ramos CL, Cohen MS, Britigan BE. Free radicals and phagocytic cells. FASEB Journal. 1995 Jan 1;9(2):200-209.
Rosen, G. M. ; Pou, S. ; Ramos, C. L. ; Cohen, M. S. ; Britigan, B. E. / Free radicals and phagocytic cells. In: FASEB Journal. 1995 ; Vol. 9, No. 2. pp. 200-209.
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