Fractalkine (CX3CL1) and brain inflammation

Implications for HIV-1-associated dementia

R. Cotter, C. Williams, David Erichsen, A. Lopez, H. Peng, Jialin C Zheng

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Leukocyte migration and activation play an important role in immune surveillance the pathogenesis of a variety of neurodegenerative disorders, including human immunodeficiency virus (HIV)-1-associated dementia (HAD). A novel chemokine named fractalkine (FKN, CX3CL1), which exists in both membrane-anchored and soluble isoforms, has been proposed to participate in the generation and progression of inflammatory brain disorders. Upon binding to the CX3C receptor one (CX3CR1), FKN induces adhesion, chemoattraction, and activation of leukocytes, including brain macrophages and microglia (MP). Constitutively expressed in the central nervous system (CNS), mainly by neurons, FKN is up-regulated and released in response to proinflammatory stimuli. Importantly, FKN is up-regulated in the brain tissue and cerebrospinal fluid (CSF) of HAD patients. Together, these observations suggest that FKN and its receptor have a unique role in regulating the neuroinflammatory events underlying disease. This review will examine how FKN contributes to the recruitment and activation of CX3CR1-expressing MP, which are critical events in the neuropathogenesis of HAD.

Original languageEnglish (US)
Pages (from-to)585-598
Number of pages14
JournalJournal of neurovirology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2002

Fingerprint

Chemokine CX3CL1
Encephalitis
Dementia
HIV-1
Leukocytes
Brain
Microglia
Brain Diseases
Chemokines
Neurodegenerative Diseases
Cerebrospinal Fluid
Protein Isoforms
Central Nervous System
Macrophages
Neurons
Membranes

Keywords

  • Chemokine receptors
  • Chemokines
  • Fractalkine
  • HIV-1-associated dementia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

Fractalkine (CX3CL1) and brain inflammation : Implications for HIV-1-associated dementia. / Cotter, R.; Williams, C.; Erichsen, David; Lopez, A.; Peng, H.; Zheng, Jialin C.

In: Journal of neurovirology, Vol. 8, No. 6, 01.12.2002, p. 585-598.

Research output: Contribution to journalReview article

Cotter, R. ; Williams, C. ; Erichsen, David ; Lopez, A. ; Peng, H. ; Zheng, Jialin C. / Fractalkine (CX3CL1) and brain inflammation : Implications for HIV-1-associated dementia. In: Journal of neurovirology. 2002 ; Vol. 8, No. 6. pp. 585-598.
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