Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues

Dhirender Singh, JoEllyn M McMillan, Xin Ming Liu, Hemant M. Vishwasrao, Alexander V. Kabanov, Marina Sokolsky-Papkov, Howard Eliot Gendelman

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5-30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.

Original languageEnglish (US)
Pages (from-to)469-485
Number of pages17
JournalNanomedicine
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Nanoparticles
diagnostic
Tissue
drug
Disease
chemistry
Magnetite Nanoparticles
evaluation
Mononuclear Phagocyte System
Ferrosoferric Oxide
Surface Properties
Poisons
Tissue regeneration
Magnetic Fields
Pharmaceutical Preparations
magnetic property
Magnetite
nanoparticle
tissue
Surface chemistry

Keywords

  • Biocompatible polymer coat
  • Drug delivery
  • MRI
  • Magnetic nanoparticle
  • Nanotoxicology
  • Protein purification
  • Superparamagnetic properties
  • Surface functionalization
  • Targeting ligands
  • Theranostics
  • Therapeutic index

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Development

Cite this

Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues. / Singh, Dhirender; McMillan, JoEllyn M; Liu, Xin Ming; Vishwasrao, Hemant M.; Kabanov, Alexander V.; Sokolsky-Papkov, Marina; Gendelman, Howard Eliot.

In: Nanomedicine, Vol. 9, No. 3, 01.01.2014, p. 469-485.

Research output: Contribution to journalReview article

Singh, Dhirender ; McMillan, JoEllyn M ; Liu, Xin Ming ; Vishwasrao, Hemant M. ; Kabanov, Alexander V. ; Sokolsky-Papkov, Marina ; Gendelman, Howard Eliot. / Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues. In: Nanomedicine. 2014 ; Vol. 9, No. 3. pp. 469-485.
@article{09e62fdf25dc4d0d9e3a7ec88a29b44f,
title = "Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues",
abstract = "Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5-30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.",
keywords = "Biocompatible polymer coat, Drug delivery, MRI, Magnetic nanoparticle, Nanotoxicology, Protein purification, Superparamagnetic properties, Surface functionalization, Targeting ligands, Theranostics, Therapeutic index",
author = "Dhirender Singh and McMillan, {JoEllyn M} and Liu, {Xin Ming} and Vishwasrao, {Hemant M.} and Kabanov, {Alexander V.} and Marina Sokolsky-Papkov and Gendelman, {Howard Eliot}",
year = "2014",
month = "1",
day = "1",
doi = "10.2217/nnm.14.4",
language = "English (US)",
volume = "9",
pages = "469--485",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "3",

}

TY - JOUR

T1 - Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues

AU - Singh, Dhirender

AU - McMillan, JoEllyn M

AU - Liu, Xin Ming

AU - Vishwasrao, Hemant M.

AU - Kabanov, Alexander V.

AU - Sokolsky-Papkov, Marina

AU - Gendelman, Howard Eliot

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5-30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.

AB - Magnetic nanoparticles (MNPs) accumulate at disease sites with the aid of magnetic fields; biodegradable MNPs can be designed to facilitate drug delivery, influence disease diagnostics, facilitate tissue regeneration and permit protein purification. Because of their limited toxicity, MNPs are widely used in theranostics, simultaneously facilitating diagnostics and therapeutics. To realize therapeutic end points, iron oxide nanoparticle cores (5-30 nm) are encapsulated in a biocompatible polymer shell with drug cargos. Although limited, the toxic potential of MNPs parallels magnetite composition, along with shape, size and surface chemistry. Clearance is hastened by the reticuloendothelial system. To surmount translational barriers, the crystal structure, particle surface and magnetic properties of MNPs need to be optimized. With this in mind, we provide a comprehensive evaluation of advancements in MNP synthesis, functionalization and design, with an eye towards bench-to-bedside translation.

KW - Biocompatible polymer coat

KW - Drug delivery

KW - MRI

KW - Magnetic nanoparticle

KW - Nanotoxicology

KW - Protein purification

KW - Superparamagnetic properties

KW - Surface functionalization

KW - Targeting ligands

KW - Theranostics

KW - Therapeutic index

UR - http://www.scopus.com/inward/record.url?scp=84899017683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899017683&partnerID=8YFLogxK

U2 - 10.2217/nnm.14.4

DO - 10.2217/nnm.14.4

M3 - Review article

VL - 9

SP - 469

EP - 485

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 3

ER -