Follicular lymphoma: Recent advances

Alyssa Bouska, Sharath Kumar Bagvati, Javeed Iqbal, Basem M. William, Wing C. Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Follicular lymphoma (FL) is a B-cell lymphoma that recapitulates the germinal center (GC)-B-cell stage of differentiation and in most cases form neoplastic follicles that resemble the normal GC. Normal GCB-cells do not express the anti-apoptotic protein B-cell leukemia/lymphoma 2 (BCL2) and they readily undergo apoptosis if they do not have a high affinity antigen receptor that will transmit survival signals on recognition of the antigen. The vast majority of FL has a translocation that leads to an inappropriate constitutive expression of the BCL2 protein that protects the cell from apoptosis. This cell can survive for long periods in the GC environment and undergoes further genetic alterations that eventually establish the neoplastic clonal population as a FL. These critical secondary changes are of great interest in understanding the evolution of a pre-neoplastic clone with BCL2 translocation to a malignant lymphoma.

Original languageEnglish (US)
Title of host publicationHematologic Cancers
Subtitle of host publicationFrom Molecular Pathobiology to Targeted Therapeutics
PublisherSpringer Netherlands
Pages21-42
Number of pages22
ISBN (Electronic)9789400750289
ISBN (Print)9789400750272
DOIs
StatePublished - Jan 1 2012

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bouska, A., Bagvati, S. K., Iqbal, J., William, B. M., & Chan, W. C. (2012). Follicular lymphoma: Recent advances. In Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics (pp. 21-42). Springer Netherlands. https://doi.org/10.1007/978-94-007-5028-9_2