Focal nodular hyperplasia: Lesion characteristics on state-of-the-art MRI including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake sequences in a prospective study

Türkan Terkivatan, Indra C. Van Den Bos, Shahid M. Hussain, Piotr A. Wielopolski, Rob A. De Man, Jan N.M. Ijzermans

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To image a cohort of patients with pathology-proven focal nodular hyperplasia (FNH) to assess which characteristics of state-of-the-art magnetic resonance imaging (MRI) of the liver are the most useful for improving the detection and characterization of FNH. Materials and Methods: In 14 patients, pathology-proven FNH (N = 33) were prospectively examined using gadolinium (Gd) and superparamagnetic iron-oxide (SPIO) contrast media. All lesions were evaluated for signal intensity (SI), fatty infiltration, central scar, mode of enhancement with Gd, and uptake of SPIO. The percentage of dynamic contrast enhancement in the arterial, portal, and delayed phases was assessed. The contrast-to-noise ratio (CNR) before and after administration of SPIO contrast was calculated. Results: The SI of the lesions was low to isointense on T1-weighted (T1W) images, and intermediate to isointense on T2W images. Fatty infiltration of the lesions was present in 6%. The percentages of enhancement in the liver and lesion were 110%, 115%, and 95%, and 151%, 182%, and 160%, respectively (P < 0.0001). All lesions showed uptake of SPIO with improved conspicuity of the central scar and septa. The CNR values precontrast and post-Gd/SPIO were significantly different for T1 in- and opposed-phase and black-blood echo-planar imaging (BBEPI). Conclusion: Combining dynamic Gd-enhanced imaging with T1W and T2W sequences after administration of SPIO facilitates comprehensive evaluation of FNH.

Original languageEnglish (US)
Pages (from-to)864-872
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume24
Issue number4
DOIs
StatePublished - Oct 1 2006

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Focal Nodular Hyperplasia
Gadolinium
Magnetic Resonance Imaging
Prospective Studies
Cicatrix
Noise
Pathology
Echo-Planar Imaging
Liver
Contrast Media
ferric oxide

Keywords

  • Contrast
  • Focal nodular hyperplasia
  • Liver
  • MRI
  • SPIO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Focal nodular hyperplasia : Lesion characteristics on state-of-the-art MRI including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake sequences in a prospective study. / Terkivatan, Türkan; Van Den Bos, Indra C.; Hussain, Shahid M.; Wielopolski, Piotr A.; De Man, Rob A.; Ijzermans, Jan N.M.

In: Journal of Magnetic Resonance Imaging, Vol. 24, No. 4, 01.10.2006, p. 864-872.

Research output: Contribution to journalArticle

Terkivatan, Türkan ; Van Den Bos, Indra C. ; Hussain, Shahid M. ; Wielopolski, Piotr A. ; De Man, Rob A. ; Ijzermans, Jan N.M. / Focal nodular hyperplasia : Lesion characteristics on state-of-the-art MRI including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake sequences in a prospective study. In: Journal of Magnetic Resonance Imaging. 2006 ; Vol. 24, No. 4. pp. 864-872.
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abstract = "Purpose: To image a cohort of patients with pathology-proven focal nodular hyperplasia (FNH) to assess which characteristics of state-of-the-art magnetic resonance imaging (MRI) of the liver are the most useful for improving the detection and characterization of FNH. Materials and Methods: In 14 patients, pathology-proven FNH (N = 33) were prospectively examined using gadolinium (Gd) and superparamagnetic iron-oxide (SPIO) contrast media. All lesions were evaluated for signal intensity (SI), fatty infiltration, central scar, mode of enhancement with Gd, and uptake of SPIO. The percentage of dynamic contrast enhancement in the arterial, portal, and delayed phases was assessed. The contrast-to-noise ratio (CNR) before and after administration of SPIO contrast was calculated. Results: The SI of the lesions was low to isointense on T1-weighted (T1W) images, and intermediate to isointense on T2W images. Fatty infiltration of the lesions was present in 6{\%}. The percentages of enhancement in the liver and lesion were 110{\%}, 115{\%}, and 95{\%}, and 151{\%}, 182{\%}, and 160{\%}, respectively (P < 0.0001). All lesions showed uptake of SPIO with improved conspicuity of the central scar and septa. The CNR values precontrast and post-Gd/SPIO were significantly different for T1 in- and opposed-phase and black-blood echo-planar imaging (BBEPI). Conclusion: Combining dynamic Gd-enhanced imaging with T1W and T2W sequences after administration of SPIO facilitates comprehensive evaluation of FNH.",
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T2 - Lesion characteristics on state-of-the-art MRI including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake sequences in a prospective study

AU - Terkivatan, Türkan

AU - Van Den Bos, Indra C.

AU - Hussain, Shahid M.

AU - Wielopolski, Piotr A.

AU - De Man, Rob A.

AU - Ijzermans, Jan N.M.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Purpose: To image a cohort of patients with pathology-proven focal nodular hyperplasia (FNH) to assess which characteristics of state-of-the-art magnetic resonance imaging (MRI) of the liver are the most useful for improving the detection and characterization of FNH. Materials and Methods: In 14 patients, pathology-proven FNH (N = 33) were prospectively examined using gadolinium (Gd) and superparamagnetic iron-oxide (SPIO) contrast media. All lesions were evaluated for signal intensity (SI), fatty infiltration, central scar, mode of enhancement with Gd, and uptake of SPIO. The percentage of dynamic contrast enhancement in the arterial, portal, and delayed phases was assessed. The contrast-to-noise ratio (CNR) before and after administration of SPIO contrast was calculated. Results: The SI of the lesions was low to isointense on T1-weighted (T1W) images, and intermediate to isointense on T2W images. Fatty infiltration of the lesions was present in 6%. The percentages of enhancement in the liver and lesion were 110%, 115%, and 95%, and 151%, 182%, and 160%, respectively (P < 0.0001). All lesions showed uptake of SPIO with improved conspicuity of the central scar and septa. The CNR values precontrast and post-Gd/SPIO were significantly different for T1 in- and opposed-phase and black-blood echo-planar imaging (BBEPI). Conclusion: Combining dynamic Gd-enhanced imaging with T1W and T2W sequences after administration of SPIO facilitates comprehensive evaluation of FNH.

AB - Purpose: To image a cohort of patients with pathology-proven focal nodular hyperplasia (FNH) to assess which characteristics of state-of-the-art magnetic resonance imaging (MRI) of the liver are the most useful for improving the detection and characterization of FNH. Materials and Methods: In 14 patients, pathology-proven FNH (N = 33) were prospectively examined using gadolinium (Gd) and superparamagnetic iron-oxide (SPIO) contrast media. All lesions were evaluated for signal intensity (SI), fatty infiltration, central scar, mode of enhancement with Gd, and uptake of SPIO. The percentage of dynamic contrast enhancement in the arterial, portal, and delayed phases was assessed. The contrast-to-noise ratio (CNR) before and after administration of SPIO contrast was calculated. Results: The SI of the lesions was low to isointense on T1-weighted (T1W) images, and intermediate to isointense on T2W images. Fatty infiltration of the lesions was present in 6%. The percentages of enhancement in the liver and lesion were 110%, 115%, and 95%, and 151%, 182%, and 160%, respectively (P < 0.0001). All lesions showed uptake of SPIO with improved conspicuity of the central scar and septa. The CNR values precontrast and post-Gd/SPIO were significantly different for T1 in- and opposed-phase and black-blood echo-planar imaging (BBEPI). Conclusion: Combining dynamic Gd-enhanced imaging with T1W and T2W sequences after administration of SPIO facilitates comprehensive evaluation of FNH.

KW - Contrast

KW - Focal nodular hyperplasia

KW - Liver

KW - MRI

KW - SPIO

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