Focal Nodular Hyperplasia: Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis

Shahid M. Hussain, Türkan Terkivatan, Pieter E. Zondervan, Esmée Lanjouw, Sjoerd De Rave, Jan N.M. Ijzermans, Rob A. De Man

Research output: Contribution to journalReview article

197 Citations (Scopus)

Abstract

Focal nodular hyperplasia (FNH) is the second most common benign liver tumor after hemangioma. FNH is classified into two types: classic (80% of cases) and nonclassic (20%). Distinction between FNH and other hypervascular liver lesions such as hepatocellular adenoma, hepatocellular carcinoma, and hypervascular metastases is critical to ensure proper treatment. An asymptomatic patient with FNH does not require biopsy or surgery. Magnetic resonance (MR) imaging has higher sensitivity and specificity for FNH than does ultrasonography or computed tomography. Typically, FNH is iso- or hypointense on T1-weighted images, is slightly hyper- or isointense on T2-weighted images, and has a hyperintense central scar on T2-weighted images. FNH demonstrates intense homogeneous enhancement during the arterial phase of gadolinium-enhanced imaging and enhancement of the central scar during later phases. Familiarity with the proper MR imaging technique and the spectrum of MR imaging findings is essential for correct diagnosis of FNH.

Original languageEnglish (US)
Pages (from-to)3-17
Number of pages15
JournalRadiographics
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Focal Nodular Hyperplasia
Magnetic Resonance Imaging
Cicatrix
Liver Cell Adenoma
Liver
Gadolinium
Hemangioma
Hepatocellular Carcinoma
Ultrasonography
Tomography
Neoplasm Metastasis
Biopsy
Sensitivity and Specificity

Keywords

  • Liver neoplasms, MR, 761.3198
  • Liver neoplasms, diagnosis, 761.3198
  • Liver, focal nodular hyperplasia, 761.3198
  • Liver, nodules, 761.3198

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hussain, S. M., Terkivatan, T., Zondervan, P. E., Lanjouw, E., De Rave, S., Ijzermans, J. N. M., & De Man, R. A. (2004). Focal Nodular Hyperplasia: Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis. Radiographics, 24(1), 3-17. https://doi.org/10.1148/rg.241035050

Focal Nodular Hyperplasia : Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis. / Hussain, Shahid M.; Terkivatan, Türkan; Zondervan, Pieter E.; Lanjouw, Esmée; De Rave, Sjoerd; Ijzermans, Jan N.M.; De Man, Rob A.

In: Radiographics, Vol. 24, No. 1, 01.01.2004, p. 3-17.

Research output: Contribution to journalReview article

Hussain, SM, Terkivatan, T, Zondervan, PE, Lanjouw, E, De Rave, S, Ijzermans, JNM & De Man, RA 2004, 'Focal Nodular Hyperplasia: Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis', Radiographics, vol. 24, no. 1, pp. 3-17. https://doi.org/10.1148/rg.241035050
Hussain SM, Terkivatan T, Zondervan PE, Lanjouw E, De Rave S, Ijzermans JNM et al. Focal Nodular Hyperplasia: Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis. Radiographics. 2004 Jan 1;24(1):3-17. https://doi.org/10.1148/rg.241035050
Hussain, Shahid M. ; Terkivatan, Türkan ; Zondervan, Pieter E. ; Lanjouw, Esmée ; De Rave, Sjoerd ; Ijzermans, Jan N.M. ; De Man, Rob A. / Focal Nodular Hyperplasia : Findings at State-of-the-Art MR Imaging, US, CT, and Pathologic Analysis. In: Radiographics. 2004 ; Vol. 24, No. 1. pp. 3-17.
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