Fluxional additives: A second generation control in enantioselective catalysis

Mukund P. Sibi, Shankar Manyem, Hector Palencia

Research output: Contribution to journalArticle

39 Scopus citations


The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.

Original languageEnglish (US)
Pages (from-to)13660-13661
Number of pages2
JournalJournal of the American Chemical Society
Issue number42
Publication statusPublished - Oct 25 2006


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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