Fluxional additives: A second generation control in enantioselective catalysis

Mukund P. Sibi, Shankar Manyem, Hector Palencia

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.

Original languageEnglish (US)
Pages (from-to)13660-13661
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number42
DOIs
StatePublished - Oct 25 2006

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Lewis Acids
Cycloaddition Reaction
Catalysis
Metals
Ligands
Cycloaddition
Enantioselectivity
Transition metals
Conformations
Acids
nitrones

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Fluxional additives : A second generation control in enantioselective catalysis. / Sibi, Mukund P.; Manyem, Shankar; Palencia, Hector.

In: Journal of the American Chemical Society, Vol. 128, No. 42, 25.10.2006, p. 13660-13661.

Research output: Contribution to journalArticle

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