Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation

ROBERT W. RICKETTS, AMANDA B. GOZA, CYNTHIA R. ELLIS, YADHU N. SINGH, NIRBHAY N. SINGH, JOHN C. COOKE

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Dysfunction of the serotonergic system has been implicated in the development and maintenance of self-injury in some persons with mental retardation. Several preliminary reports have suggested that fluoxetine, a drug that blocks the reuptake of serotonin, may decrease self-injury in these individuals. Of the 44 cases of self-injury treated with fluoxetine and previously reported in the literature, 42 demonstrated a beneficial response to the drug. We report four additional cases of adults with mental retardation whose self-injury was treated with fluoxetine. Each of these individuals benefited from fluoxetine to some extent, with average decreases in self-injury ranging from 20% to 88% when compared with baseline levels. These findings, combined with those from previously published case studies, emphasize the need for well-controlled studies to more adequately assess the effects of fluoxetine on self-injury.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume32
Issue number4
DOIs
StatePublished - Jan 1 1993

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Fluoxetine
Intellectual Disability
Young Adult
Wounds and Injuries
Therapeutics
Pharmaceutical Preparations
Serotonin

Keywords

  • fluoxetine
  • mental retardation
  • self-injury
  • serotonergic dysfunction

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation. / RICKETTS, ROBERT W.; GOZA, AMANDA B.; ELLIS, CYNTHIA R.; SINGH, YADHU N.; SINGH, NIRBHAY N.; COOKE, JOHN C.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 32, No. 4, 01.01.1993, p. 865-869.

Research output: Contribution to journalArticle

RICKETTS, ROBERT W. ; GOZA, AMANDA B. ; ELLIS, CYNTHIA R. ; SINGH, YADHU N. ; SINGH, NIRBHAY N. ; COOKE, JOHN C. / Fluoxetine Treatment of Severe Self-Injury in Young Adults with Mental Retardation. In: Journal of the American Academy of Child and Adolescent Psychiatry. 1993 ; Vol. 32, No. 4. pp. 865-869.
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