Fluoxetine, smoking, and history of major depression

A randomized controlled trial

Bonnie Spring, Neal Doran, Sherry Pagoto, Dennis E McChargue, Jessica Werth Cook, Katherine Bailey, John Crayton, Donald Hedeker

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p =.02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p =.02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalJournal of Consulting and Clinical Psychology
Volume75
Issue number1
DOIs
StatePublished - Feb 1 2007

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Fluoxetine
Randomized Controlled Trials
Smoking
Depression
Placebos
Tobacco
History
Research

Keywords

  • Depression
  • Fluoxetine
  • Randomized controlled trial
  • Smoking cessation
  • Tobacco

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Fluoxetine, smoking, and history of major depression : A randomized controlled trial. / Spring, Bonnie; Doran, Neal; Pagoto, Sherry; McChargue, Dennis E; Cook, Jessica Werth; Bailey, Katherine; Crayton, John; Hedeker, Donald.

In: Journal of Consulting and Clinical Psychology, Vol. 75, No. 1, 01.02.2007, p. 85-94.

Research output: Contribution to journalArticle

Spring, Bonnie ; Doran, Neal ; Pagoto, Sherry ; McChargue, Dennis E ; Cook, Jessica Werth ; Bailey, Katherine ; Crayton, John ; Hedeker, Donald. / Fluoxetine, smoking, and history of major depression : A randomized controlled trial. In: Journal of Consulting and Clinical Psychology. 2007 ; Vol. 75, No. 1. pp. 85-94.
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