FluGenome: A web tool for genotyping influenza A virus

Guoqing Lu, Thaine Rowley, Rebecca Garten, Ruben O. Donis

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Influenza A viruses are hosted by numerous avian and mammalian species, which have shaped their evolution into distinct lineages worldwide. The viral genome consists of eight RNA segments that are frequently exchanged between different viruses via a process known as genetic reassortment. A complete genotype nomenclature is essential to describe gene segment reassortment. Specialized bioinformatic tools to analyze reassortment are not available, which hampers progress in understanding its role in host range, virulence and transmissibility of influenza viruses. To meet this need, we have developed a nomenclature to name influenza A genotypes and implemented a web server, FluGenome (http://www.flugenome.org/), for the assignment of lineages and genotypes. FluGenome provides functions for the user to interrogate the database in different modalities and get detailed reports on lineages and genotypes. These features make FluGenome unique in its ability to automatically detect genotype differences attributable to reassortment events in influenza A virus evolution.

Original languageEnglish (US)
Pages (from-to)W275-W279
JournalNucleic acids research
Volume35
Issue numberSUPPL.2
DOIs
StatePublished - Jul 1 2007

Fingerprint

Influenza A virus
Genotype
Terminology
Viral Genome
Host Specificity
Orthomyxoviridae
Computational Biology
Human Influenza
Names
Virulence
Databases
RNA
Viruses
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

FluGenome : A web tool for genotyping influenza A virus. / Lu, Guoqing; Rowley, Thaine; Garten, Rebecca; Donis, Ruben O.

In: Nucleic acids research, Vol. 35, No. SUPPL.2, 01.07.2007, p. W275-W279.

Research output: Contribution to journalArticle

Lu, G, Rowley, T, Garten, R & Donis, RO 2007, 'FluGenome: A web tool for genotyping influenza A virus', Nucleic acids research, vol. 35, no. SUPPL.2, pp. W275-W279. https://doi.org/10.1093/nar/gkm365
Lu, Guoqing ; Rowley, Thaine ; Garten, Rebecca ; Donis, Ruben O. / FluGenome : A web tool for genotyping influenza A virus. In: Nucleic acids research. 2007 ; Vol. 35, No. SUPPL.2. pp. W275-W279.
@article{5af5930b86ec417e8868ae7fff12d665,
title = "FluGenome: A web tool for genotyping influenza A virus",
abstract = "Influenza A viruses are hosted by numerous avian and mammalian species, which have shaped their evolution into distinct lineages worldwide. The viral genome consists of eight RNA segments that are frequently exchanged between different viruses via a process known as genetic reassortment. A complete genotype nomenclature is essential to describe gene segment reassortment. Specialized bioinformatic tools to analyze reassortment are not available, which hampers progress in understanding its role in host range, virulence and transmissibility of influenza viruses. To meet this need, we have developed a nomenclature to name influenza A genotypes and implemented a web server, FluGenome (http://www.flugenome.org/), for the assignment of lineages and genotypes. FluGenome provides functions for the user to interrogate the database in different modalities and get detailed reports on lineages and genotypes. These features make FluGenome unique in its ability to automatically detect genotype differences attributable to reassortment events in influenza A virus evolution.",
author = "Guoqing Lu and Thaine Rowley and Rebecca Garten and Donis, {Ruben O.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1093/nar/gkm365",
language = "English (US)",
volume = "35",
pages = "W275--W279",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "SUPPL.2",

}

TY - JOUR

T1 - FluGenome

T2 - A web tool for genotyping influenza A virus

AU - Lu, Guoqing

AU - Rowley, Thaine

AU - Garten, Rebecca

AU - Donis, Ruben O.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Influenza A viruses are hosted by numerous avian and mammalian species, which have shaped their evolution into distinct lineages worldwide. The viral genome consists of eight RNA segments that are frequently exchanged between different viruses via a process known as genetic reassortment. A complete genotype nomenclature is essential to describe gene segment reassortment. Specialized bioinformatic tools to analyze reassortment are not available, which hampers progress in understanding its role in host range, virulence and transmissibility of influenza viruses. To meet this need, we have developed a nomenclature to name influenza A genotypes and implemented a web server, FluGenome (http://www.flugenome.org/), for the assignment of lineages and genotypes. FluGenome provides functions for the user to interrogate the database in different modalities and get detailed reports on lineages and genotypes. These features make FluGenome unique in its ability to automatically detect genotype differences attributable to reassortment events in influenza A virus evolution.

AB - Influenza A viruses are hosted by numerous avian and mammalian species, which have shaped their evolution into distinct lineages worldwide. The viral genome consists of eight RNA segments that are frequently exchanged between different viruses via a process known as genetic reassortment. A complete genotype nomenclature is essential to describe gene segment reassortment. Specialized bioinformatic tools to analyze reassortment are not available, which hampers progress in understanding its role in host range, virulence and transmissibility of influenza viruses. To meet this need, we have developed a nomenclature to name influenza A genotypes and implemented a web server, FluGenome (http://www.flugenome.org/), for the assignment of lineages and genotypes. FluGenome provides functions for the user to interrogate the database in different modalities and get detailed reports on lineages and genotypes. These features make FluGenome unique in its ability to automatically detect genotype differences attributable to reassortment events in influenza A virus evolution.

UR - http://www.scopus.com/inward/record.url?scp=34547558387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547558387&partnerID=8YFLogxK

U2 - 10.1093/nar/gkm365

DO - 10.1093/nar/gkm365

M3 - Article

C2 - 17537820

AN - SCOPUS:34547558387

VL - 35

SP - W275-W279

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - SUPPL.2

ER -