Flow characterization of microfluidic paper-based analytical devices with hollow channels

Haipeng Zhang, Danielle Barmore, Sangjin Ryu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microfluidic paper-based analytical devices (µPADs) are cost-effective point-of-care diagnostic devices. µPADs consist of porous filter paper patterned with hydrophobic solid ink barriers to create flow channels. Because a liquid sample flows through the paper channel driven by capillary force, the resultant flow is usually slow. To overcome this limitation, a hollow channel can be added to a µPAD to increase the flow speed significantly. The liquid flow through the hollow channel is known to be driven by a pressure difference between the inlet and outlet of the device. Accordingly, theoretical models have been proposed to understand and predict flow characteristics of µPADs with hollow channels. The goal of this study is to experimentally characterize liquid flow through µPADs having a hollow channel, by investigating relationships among the travel distance of the liquid front through the µPADs, the applied pressure difference, and the dimension of the hollow channel. Thus, the outcome of this study would contribute to validating the theoretical models and enable better control of liquid sample flow in µPADs with hollow channels.

Original languageEnglish (US)
Title of host publicationFluid Measurement and Instrumentation; Micro and Nano Fluid Dynamics
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791859070
DOIs
StatePublished - Jan 1 2019
EventASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019 - San Francisco, United States
Duration: Jul 28 2019Aug 1 2019

Publication series

NameASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019
Volume4

Conference

ConferenceASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019
CountryUnited States
CitySan Francisco
Period7/28/198/1/19

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Keywords

  • Capillary flow
  • Poiseuille flow
  • Pressure-driven flow
  • Scaling law
  • Washburn law

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

Cite this

Zhang, H., Barmore, D., & Ryu, S. (2019). Flow characterization of microfluidic paper-based analytical devices with hollow channels. In Fluid Measurement and Instrumentation; Micro and Nano Fluid Dynamics (ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019; Vol. 4). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/AJKFluids2019-5502