Flavin redox switching of protein functions

Donald F Becker, Weidong Zhu, Michael A. Moxley

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Flavin cofactors impart remarkable catalytic diversity to enzymes, enabling them to participate in a broad array of biological processes. The properties of flavins also provide proteins with a versatile redox sensor that can be utilized for converting physiological signals such as cellular metabolism, light, and redox status into a unique functional output. The control of protein functions by the flavin redox state is important for transcriptional regulation, cell signaling pathways, and environmental adaptation. A significant number of proteins that have flavin redox switches are found in the Per-Arnt-Sim (PAS) domain family and include flavoproteins that act as photosensors and respond to changes in cellular redox conditions. Biochemical and structural studies of PAS domain flavoproteins have revealed key insights into how flavin redox changes are propagated to the surface of the protein and translated into a new functional output such as the binding of a target protein in a signaling pathway. Mechanistic details of proteins unrelated to the PAS domain are also emerging and provide novel examples of how the flavin redox state governs protein-membrane interactions in response to appropriate stimuli. Analysis of different flavin switch proteins reveals shared mechanistic themes for the regulation of protein structure and function by flavins.

Original languageEnglish (US)
Pages (from-to)1079-1091
Number of pages13
JournalAntioxidants and Redox Signaling
Volume14
Issue number6
DOIs
StatePublished - Mar 15 2011

Fingerprint

Oxidation-Reduction
Flavins
Proteins
Flavoproteins
Membrane Proteins
Switches
Cell signaling
Biological Phenomena
4,6-dinitro-o-cresol
Metabolism
Light
Sensors
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Flavin redox switching of protein functions. / Becker, Donald F; Zhu, Weidong; Moxley, Michael A.

In: Antioxidants and Redox Signaling, Vol. 14, No. 6, 15.03.2011, p. 1079-1091.

Research output: Contribution to journalReview article

Becker, Donald F ; Zhu, Weidong ; Moxley, Michael A. / Flavin redox switching of protein functions. In: Antioxidants and Redox Signaling. 2011 ; Vol. 14, No. 6. pp. 1079-1091.
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