First-line treatment of patients with chronic-phase chronic myelogenous leukemia: Progress and remaining questions

Research output: Contribution to journalReview article

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Abstract

Imatinib is the standard first-line therapy for chronic-phase chronic myelogenous leukemia (CP CML). However, only 57% of patients in the key IRIS (International Randomized Study of Interferon and STI571) study now remain on imatinib per protocol with complete cytogenetic response (CCyR), and the lost follow-up on off-protocol patients precludes accurately determining efficacy and long-term survival. The UK front-line study, an intent-to-treat analysis of patients with newly diagnosed CP CML, supports the data generated by IRIS, with follow-up data available for all enrollees. This study suggests that patients who fail to achieve hematologic and cytogenetic responses by specified timepoints have inferior progression-free and overall survival and are thus intriguing targets for therapeutic intervention. This review discusses the results of the UK and other studies and evaluates available second-line treatment options for patients with CP CML.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalCommunity Oncology
Volume7
Issue number4
DOIs
StatePublished - Apr 2010

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ASJC Scopus subject areas

  • Hematology
  • Oncology

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