Finite element analysis of covered microstents

Linxia Gu, Swadeshmukul Santra, Robert A. Mericle, Ashok V. Kumar

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Currently available neuroendovascular devices are inadequate for effective treatment of many wide-necked or fusiform intracranial aneurysms and intracranial carotid-cavernous fistulae (CCF). Placing a covered microstent across the intracranial aneurysm neck and CCF rent could restore normal vessel morphology by preventing blood flow into the aneurysm lumen or CCF rent. To fabricate covered microstents, our research group has developed highly flexible ultra thin (∼150 μm) silicone coverings and elastomerically captured them onto commercially available metal stents without stitching. Preliminary in vivo studies were conducted by placing these covered microstents in the common carotid artery of rabbits. The feasibility of using covered stents was demonstrated. However, the cover affected the deployment pressure and the stents failed occasionally during deployment due to tearing of the cover. Appropriate modeling of covered stents will assist in designing suitable coverings, and help to reduce the failure rate of covered microstents. The purpose of this study is to use the finite element method to determine the mechanical properties of the covered microstent and investigate the effects of the covering on the mechanical behavior of the covered microstent. Variations in the mechanical properties of the covered microstent such as deployment pressure, elastic recoil and longitudinal shortening due to change in thickness and material properties of the cover have been investigated. This work is also important for custom design of covered microstents such as adding cutout holes to save adjacent perforating arteries.

Original languageEnglish (US)
Pages (from-to)1221-1227
Number of pages7
JournalJournal of Biomechanics
Volume38
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Finite Element Analysis
Stents
Fistula
Finite element method
Intracranial Aneurysm
Aneurysm
Perforating
Pressure
Mechanical properties
Common Carotid Artery
Silicones
Materials properties
Blood
Arteries
Metals
Rabbits
Equipment and Supplies
Research

Keywords

  • Aneurysm
  • Arteriovenous fistula
  • Covered stent
  • Finite element analysis
  • Silicone
  • Simulation

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

Finite element analysis of covered microstents. / Gu, Linxia; Santra, Swadeshmukul; Mericle, Robert A.; Kumar, Ashok V.

In: Journal of Biomechanics, Vol. 38, No. 6, 06.2005, p. 1221-1227.

Research output: Contribution to journalArticle

Gu, L, Santra, S, Mericle, RA & Kumar, AV 2005, 'Finite element analysis of covered microstents', Journal of Biomechanics, vol. 38, no. 6, pp. 1221-1227. https://doi.org/10.1016/j.jbiomech.2004.06.008
Gu, Linxia ; Santra, Swadeshmukul ; Mericle, Robert A. ; Kumar, Ashok V. / Finite element analysis of covered microstents. In: Journal of Biomechanics. 2005 ; Vol. 38, No. 6. pp. 1221-1227.
@article{aa82bbc920244ed1b6492664b212a663,
title = "Finite element analysis of covered microstents",
abstract = "Currently available neuroendovascular devices are inadequate for effective treatment of many wide-necked or fusiform intracranial aneurysms and intracranial carotid-cavernous fistulae (CCF). Placing a covered microstent across the intracranial aneurysm neck and CCF rent could restore normal vessel morphology by preventing blood flow into the aneurysm lumen or CCF rent. To fabricate covered microstents, our research group has developed highly flexible ultra thin (∼150 μm) silicone coverings and elastomerically captured them onto commercially available metal stents without stitching. Preliminary in vivo studies were conducted by placing these covered microstents in the common carotid artery of rabbits. The feasibility of using covered stents was demonstrated. However, the cover affected the deployment pressure and the stents failed occasionally during deployment due to tearing of the cover. Appropriate modeling of covered stents will assist in designing suitable coverings, and help to reduce the failure rate of covered microstents. The purpose of this study is to use the finite element method to determine the mechanical properties of the covered microstent and investigate the effects of the covering on the mechanical behavior of the covered microstent. Variations in the mechanical properties of the covered microstent such as deployment pressure, elastic recoil and longitudinal shortening due to change in thickness and material properties of the cover have been investigated. This work is also important for custom design of covered microstents such as adding cutout holes to save adjacent perforating arteries.",
keywords = "Aneurysm, Arteriovenous fistula, Covered stent, Finite element analysis, Silicone, Simulation",
author = "Linxia Gu and Swadeshmukul Santra and Mericle, {Robert A.} and Kumar, {Ashok V.}",
year = "2005",
month = "6",
doi = "10.1016/j.jbiomech.2004.06.008",
language = "English (US)",
volume = "38",
pages = "1221--1227",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Finite element analysis of covered microstents

AU - Gu, Linxia

AU - Santra, Swadeshmukul

AU - Mericle, Robert A.

AU - Kumar, Ashok V.

PY - 2005/6

Y1 - 2005/6

N2 - Currently available neuroendovascular devices are inadequate for effective treatment of many wide-necked or fusiform intracranial aneurysms and intracranial carotid-cavernous fistulae (CCF). Placing a covered microstent across the intracranial aneurysm neck and CCF rent could restore normal vessel morphology by preventing blood flow into the aneurysm lumen or CCF rent. To fabricate covered microstents, our research group has developed highly flexible ultra thin (∼150 μm) silicone coverings and elastomerically captured them onto commercially available metal stents without stitching. Preliminary in vivo studies were conducted by placing these covered microstents in the common carotid artery of rabbits. The feasibility of using covered stents was demonstrated. However, the cover affected the deployment pressure and the stents failed occasionally during deployment due to tearing of the cover. Appropriate modeling of covered stents will assist in designing suitable coverings, and help to reduce the failure rate of covered microstents. The purpose of this study is to use the finite element method to determine the mechanical properties of the covered microstent and investigate the effects of the covering on the mechanical behavior of the covered microstent. Variations in the mechanical properties of the covered microstent such as deployment pressure, elastic recoil and longitudinal shortening due to change in thickness and material properties of the cover have been investigated. This work is also important for custom design of covered microstents such as adding cutout holes to save adjacent perforating arteries.

AB - Currently available neuroendovascular devices are inadequate for effective treatment of many wide-necked or fusiform intracranial aneurysms and intracranial carotid-cavernous fistulae (CCF). Placing a covered microstent across the intracranial aneurysm neck and CCF rent could restore normal vessel morphology by preventing blood flow into the aneurysm lumen or CCF rent. To fabricate covered microstents, our research group has developed highly flexible ultra thin (∼150 μm) silicone coverings and elastomerically captured them onto commercially available metal stents without stitching. Preliminary in vivo studies were conducted by placing these covered microstents in the common carotid artery of rabbits. The feasibility of using covered stents was demonstrated. However, the cover affected the deployment pressure and the stents failed occasionally during deployment due to tearing of the cover. Appropriate modeling of covered stents will assist in designing suitable coverings, and help to reduce the failure rate of covered microstents. The purpose of this study is to use the finite element method to determine the mechanical properties of the covered microstent and investigate the effects of the covering on the mechanical behavior of the covered microstent. Variations in the mechanical properties of the covered microstent such as deployment pressure, elastic recoil and longitudinal shortening due to change in thickness and material properties of the cover have been investigated. This work is also important for custom design of covered microstents such as adding cutout holes to save adjacent perforating arteries.

KW - Aneurysm

KW - Arteriovenous fistula

KW - Covered stent

KW - Finite element analysis

KW - Silicone

KW - Simulation

UR - http://www.scopus.com/inward/record.url?scp=18044372225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18044372225&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2004.06.008

DO - 10.1016/j.jbiomech.2004.06.008

M3 - Article

C2 - 15863106

AN - SCOPUS:18044372225

VL - 38

SP - 1221

EP - 1227

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 6

ER -