Fibronectin in human bronchopulmonary lavage fluid. Elevation in patients with interstitial lung disease

S. I. Rennard, R. G. Crystal

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Fibronectin is a major adhesive and opsonic glycoprotein found in plasma and tissues. Because this molecule appears to mediate a number of interactions between cells and extracellular matrix, and because the interstitial lung diseases are characterized by marked derangements of the pulmonary extracellular matrix, we evaluated fibronectin in the lower respiratory tract in patients with these disorders. Fibronectin could be detected in the bronchoalveolar lavage fluid of normals (11/11), as well as those with noninterstitial lung diseases (18/18), idiopathic pulmonary fibrosis (21/21), sarcoidosis (20/20), and other interstitial lung diseases (22/22). Compared with normal and those with noninterstitial lung disease, the levels in bronchoalveolar lavage of patients with interstitial disease were significantly higher (P < 0.01, all comparisons). This was true only for bronchoalveolar lavage fibronectin; plasma levels were similar in all study groups (P > 0.2, all comparisons). The lavage fluid fibronectin was intact antigenically and retained collagen binding capability, although in some cases of interstitial disease, the presence of lower molecular weight fragments suggested some degradation. Thus, fibronectin is a normal constituent of the epithelial fluid of the lower respiratory tract and is present in increased amounts in a significant number of individuals with interstitial lung disease.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalJournal of Clinical Investigation
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1982

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Interstitial Lung Diseases
Bronchoalveolar Lavage
Fibronectins
Respiratory System
Lung Diseases
Extracellular Matrix
Idiopathic Pulmonary Fibrosis
Therapeutic Irrigation
Bronchoalveolar Lavage Fluid
Sarcoidosis
Cell Communication
Adhesives
Collagen
Molecular Weight
Lung

ASJC Scopus subject areas

  • Medicine(all)

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Fibronectin in human bronchopulmonary lavage fluid. Elevation in patients with interstitial lung disease. / Rennard, S. I.; Crystal, R. G.

In: Journal of Clinical Investigation, Vol. 69, No. 1, 01.01.1982, p. 113-122.

Research output: Contribution to journalArticle

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