Abstract

Fibronectin is a glycoprotein consisting of repeating units of amino acids, which form domains that enable the molecule to interact with a variety of cells through both integrin and non-integrin receptors. It is encoded by a single gene, but alternative splicing of pre-mRNA allows formation of multiple isoforms that have critical roles in cell adhesion, migration and proliferation. The essential nature of fibronectin in development has clearly been demonstrated in a 'knock-out' mouse model in which early lethality occurs. Fibronectin influences diverse processes including inflammation, wound repair, malignant metastasis, microorganism attachment and thrombosis. Researchers are currently developing tools, including synthetic peptides based on specific fibronectin regions. These molecules have been shown to alter processes such as lymphocyte binding in synovial tissue of rheumatoid arthritis, coronary arteriopathy in animal models of cardiac transplantation, and platelet aggregation in patients, and are thus providing important new therapeutic possibilities.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume29
Issue number7
DOIs
StatePublished - Jan 1 1997

Fingerprint

Fibronectins
Molecules
Lymphocytes
RNA Precursors
Cell adhesion
Alternative Splicing
Heart Transplantation
Platelets
Platelet Aggregation
Knockout Mice
Cell Adhesion
Integrins
Microorganisms
Cell Movement
Rheumatoid Arthritis
Glycoproteins
Protein Isoforms
Animals
Thrombosis
Repair

Keywords

  • Cell-cell interactions
  • Extracellular matrix
  • Fibronectin
  • mRNA splicing

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Fibronectin. / Romberger, Debra.

In: International Journal of Biochemistry and Cell Biology, Vol. 29, No. 7, 01.01.1997, p. 939-943.

Research output: Contribution to journalArticle

@article{b9c87302c8804f1a929b523f47675d95,
title = "Fibronectin",
abstract = "Fibronectin is a glycoprotein consisting of repeating units of amino acids, which form domains that enable the molecule to interact with a variety of cells through both integrin and non-integrin receptors. It is encoded by a single gene, but alternative splicing of pre-mRNA allows formation of multiple isoforms that have critical roles in cell adhesion, migration and proliferation. The essential nature of fibronectin in development has clearly been demonstrated in a 'knock-out' mouse model in which early lethality occurs. Fibronectin influences diverse processes including inflammation, wound repair, malignant metastasis, microorganism attachment and thrombosis. Researchers are currently developing tools, including synthetic peptides based on specific fibronectin regions. These molecules have been shown to alter processes such as lymphocyte binding in synovial tissue of rheumatoid arthritis, coronary arteriopathy in animal models of cardiac transplantation, and platelet aggregation in patients, and are thus providing important new therapeutic possibilities.",
keywords = "Cell-cell interactions, Extracellular matrix, Fibronectin, mRNA splicing",
author = "Debra Romberger",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S1357-2725(96)00172-0",
language = "English (US)",
volume = "29",
pages = "939--943",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Fibronectin

AU - Romberger, Debra

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Fibronectin is a glycoprotein consisting of repeating units of amino acids, which form domains that enable the molecule to interact with a variety of cells through both integrin and non-integrin receptors. It is encoded by a single gene, but alternative splicing of pre-mRNA allows formation of multiple isoforms that have critical roles in cell adhesion, migration and proliferation. The essential nature of fibronectin in development has clearly been demonstrated in a 'knock-out' mouse model in which early lethality occurs. Fibronectin influences diverse processes including inflammation, wound repair, malignant metastasis, microorganism attachment and thrombosis. Researchers are currently developing tools, including synthetic peptides based on specific fibronectin regions. These molecules have been shown to alter processes such as lymphocyte binding in synovial tissue of rheumatoid arthritis, coronary arteriopathy in animal models of cardiac transplantation, and platelet aggregation in patients, and are thus providing important new therapeutic possibilities.

AB - Fibronectin is a glycoprotein consisting of repeating units of amino acids, which form domains that enable the molecule to interact with a variety of cells through both integrin and non-integrin receptors. It is encoded by a single gene, but alternative splicing of pre-mRNA allows formation of multiple isoforms that have critical roles in cell adhesion, migration and proliferation. The essential nature of fibronectin in development has clearly been demonstrated in a 'knock-out' mouse model in which early lethality occurs. Fibronectin influences diverse processes including inflammation, wound repair, malignant metastasis, microorganism attachment and thrombosis. Researchers are currently developing tools, including synthetic peptides based on specific fibronectin regions. These molecules have been shown to alter processes such as lymphocyte binding in synovial tissue of rheumatoid arthritis, coronary arteriopathy in animal models of cardiac transplantation, and platelet aggregation in patients, and are thus providing important new therapeutic possibilities.

KW - Cell-cell interactions

KW - Extracellular matrix

KW - Fibronectin

KW - mRNA splicing

UR - http://www.scopus.com/inward/record.url?scp=0030723421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030723421&partnerID=8YFLogxK

U2 - 10.1016/S1357-2725(96)00172-0

DO - 10.1016/S1357-2725(96)00172-0

M3 - Article

VL - 29

SP - 939

EP - 943

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 7

ER -