Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs

S. I. Rennard, J. Moss, J. Oberpriller, B. Hom, L. Stier, T. Ozaki, R. G. Crystal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To evaluate whether such prostaglandins can alter lung connective tissue secretion by lung fibroblasts, the ability of prostaglandins to modulate the secretion of collagen and fibronectin by HFL-1 cells was determined using an enzyme immunoassay for human type I collagen and for human fibronectin. PGE 1 and PGE 2 caused a 29 ± 6% reduction in type I collagen secretion but, in contrast, a 39 ± 7% increase in fibronectin secretion (p < 0.01, all comparisons to control). In contrast, PGF(2α), (a prostaglandin which frequently has effects opposite those of PGE 1 and PGE 2 ) had no effect on type I collagen secretion (99 ± 7% of control, p > 0.2) bu caused a 20 ± 3% reduction in fibronectin secretion (p < 0.05). Thus fibroblasts are capable of specific modulation of connective macromolecule secretion in response to progstaglandins. Both through the production of prostaglandins and as a target for these mediators, lung fibroblasts play an important role in the cellular response to lung inflammation.

Original languageEnglish (US)
Pages (from-to)92S-93S
JournalUnknown Journal
Volume83
Issue number5 Suppl.
StatePublished - Jan 1 1983

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Fibroblasts
Prostaglandins E
Fibronectins
Prostaglandins
Collagen Type I
Lung
Prostaglandins F
Macromolecules
Immunoenzyme Techniques
Connective Tissue
Pneumonia
Collagen
Modulation
Tissue
Enzymes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Rennard, S. I., Moss, J., Oberpriller, J., Hom, B., Stier, L., Ozaki, T., & Crystal, R. G. (1983). Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs. Unknown Journal, 83(5 Suppl.), 92S-93S.

Fibroblasts : Important producers and targets of inflammatory prostaglandins in the lungs. / Rennard, S. I.; Moss, J.; Oberpriller, J.; Hom, B.; Stier, L.; Ozaki, T.; Crystal, R. G.

In: Unknown Journal, Vol. 83, No. 5 Suppl., 01.01.1983, p. 92S-93S.

Research output: Contribution to journalArticle

Rennard, SI, Moss, J, Oberpriller, J, Hom, B, Stier, L, Ozaki, T & Crystal, RG 1983, 'Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs', Unknown Journal, vol. 83, no. 5 Suppl., pp. 92S-93S.
Rennard SI, Moss J, Oberpriller J, Hom B, Stier L, Ozaki T et al. Fibroblasts: Important producers and targets of inflammatory prostaglandins in the lungs. Unknown Journal. 1983 Jan 1;83(5 Suppl.):92S-93S.
Rennard, S. I. ; Moss, J. ; Oberpriller, J. ; Hom, B. ; Stier, L. ; Ozaki, T. ; Crystal, R. G. / Fibroblasts : Important producers and targets of inflammatory prostaglandins in the lungs. In: Unknown Journal. 1983 ; Vol. 83, No. 5 Suppl. pp. 92S-93S.
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