Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles

Sung-Ho Huh, Katja Närhi, Päivi H. Lindfors, Otso Häärä, Lu Yang, David M. Ornitz, Marja L. Mikkola

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

In hair follicle development, a placode-derived signal is believed to induce formation of the dermal condensation, an essential component of ectodermal organs. However, the identity of this signal is unknown. Furthermore, although induction and patterning of hair follicles are intimately linked, it is not known whether the mesenchymal condensation is necessary for inducing the initial epithelial pattern. Here, we show that fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/β-Catenin signaling to initiate formation of the underlying dermal condensation. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles and subsequent formation of guard, awl, and auchene hairs. Although primary dermal condensations are absent in Fgf20 mutant mice, a regular array of hair placodes is formed, demonstrating that the epithelial patterning process is independent of known histological and molecular markers of underlying mesenchymal patterns during the initial stages of hair follicle development.

Original languageEnglish (US)
Pages (from-to)450-458
Number of pages9
JournalGenes and Development
Volume27
Issue number4
DOIs
StatePublished - Feb 15 2013

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Fibroblast Growth Factors
Hair Follicle
Skin
Ectodysplasins
Catenins

Keywords

  • Dermal condensation initiation
  • Eda signal
  • Fgf20
  • Hair follicle development
  • Mesenchymal-epithelial interactions
  • Wnt signal

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Huh, S-H., Närhi, K., Lindfors, P. H., Häärä, O., Yang, L., Ornitz, D. M., & Mikkola, M. L. (2013). Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes and Development, 27(4), 450-458. https://doi.org/10.1101/gad.198945.112

Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. / Huh, Sung-Ho; Närhi, Katja; Lindfors, Päivi H.; Häärä, Otso; Yang, Lu; Ornitz, David M.; Mikkola, Marja L.

In: Genes and Development, Vol. 27, No. 4, 15.02.2013, p. 450-458.

Research output: Contribution to journalArticle

Huh, S-H, Närhi, K, Lindfors, PH, Häärä, O, Yang, L, Ornitz, DM & Mikkola, ML 2013, 'Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles', Genes and Development, vol. 27, no. 4, pp. 450-458. https://doi.org/10.1101/gad.198945.112
Huh, Sung-Ho ; Närhi, Katja ; Lindfors, Päivi H. ; Häärä, Otso ; Yang, Lu ; Ornitz, David M. ; Mikkola, Marja L. / Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. In: Genes and Development. 2013 ; Vol. 27, No. 4. pp. 450-458.
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