FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area

Lu M. Yang, Sung-Ho Huh, David M. Ornitz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. Here, we use engineered fibroblast growth factor 20 (Fgf20) knockin alleles to identify a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE. We show that these Fgf20-positive epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny and positively regulates Fgf20 expression. We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates. Mechanisms regulating olfactory epithelium expansion and turbinate growth are poorly understood. In this issue of Developmental Cell, Yang et al. show that an Fgf20-expressing progenitor (FEP) expands the olfactory epithelium and regulates turbinate growth via FGF20. Furthermore, Wnt/β-Catenin signaling acts as a master regulator of these two processes.

Original languageEnglish (US)
Pages (from-to)564-580.e5
JournalDevelopmental cell
Volume46
Issue number5
DOIs
StatePublished - Sep 10 2018

Fingerprint

Olfactory Mucosa
Turbinates
Fibroblast Growth Factors
Catenins
Growth
Stem Cells
Nasal Cavity
Epithelium
Smell
Mesoderm
Population
Cell Differentiation
Alleles

Keywords

  • FGF20
  • Wnt/β-Catenin
  • condensation
  • olfactory epithelium
  • progenitor cell
  • tissue scaling
  • turbinate

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. / Yang, Lu M.; Huh, Sung-Ho; Ornitz, David M.

In: Developmental cell, Vol. 46, No. 5, 10.09.2018, p. 564-580.e5.

Research output: Contribution to journalArticle

@article{2fe21dcdb0db436fba62d551f65b9667,
title = "FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area",
abstract = "The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. Here, we use engineered fibroblast growth factor 20 (Fgf20) knockin alleles to identify a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE. We show that these Fgf20-positive epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny and positively regulates Fgf20 expression. We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates. Mechanisms regulating olfactory epithelium expansion and turbinate growth are poorly understood. In this issue of Developmental Cell, Yang et al. show that an Fgf20-expressing progenitor (FEP) expands the olfactory epithelium and regulates turbinate growth via FGF20. Furthermore, Wnt/β-Catenin signaling acts as a master regulator of these two processes.",
keywords = "FGF20, Wnt/β-Catenin, condensation, olfactory epithelium, progenitor cell, tissue scaling, turbinate",
author = "Yang, {Lu M.} and Sung-Ho Huh and Ornitz, {David M.}",
year = "2018",
month = "9",
day = "10",
doi = "10.1016/j.devcel.2018.07.010",
language = "English (US)",
volume = "46",
pages = "564--580.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area

AU - Yang, Lu M.

AU - Huh, Sung-Ho

AU - Ornitz, David M.

PY - 2018/9/10

Y1 - 2018/9/10

N2 - The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. Here, we use engineered fibroblast growth factor 20 (Fgf20) knockin alleles to identify a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE. We show that these Fgf20-positive epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny and positively regulates Fgf20 expression. We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates. Mechanisms regulating olfactory epithelium expansion and turbinate growth are poorly understood. In this issue of Developmental Cell, Yang et al. show that an Fgf20-expressing progenitor (FEP) expands the olfactory epithelium and regulates turbinate growth via FGF20. Furthermore, Wnt/β-Catenin signaling acts as a master regulator of these two processes.

AB - The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. Here, we use engineered fibroblast growth factor 20 (Fgf20) knockin alleles to identify a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE. We show that these Fgf20-positive epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny and positively regulates Fgf20 expression. We further show that FGF20 signals to the underlying mesenchyme to regulate the growth of turbinates. These studies thus identify a population of OE progenitor cells that function to scale OE surface area with the underlying turbinates. Mechanisms regulating olfactory epithelium expansion and turbinate growth are poorly understood. In this issue of Developmental Cell, Yang et al. show that an Fgf20-expressing progenitor (FEP) expands the olfactory epithelium and regulates turbinate growth via FGF20. Furthermore, Wnt/β-Catenin signaling acts as a master regulator of these two processes.

KW - FGF20

KW - Wnt/β-Catenin

KW - condensation

KW - olfactory epithelium

KW - progenitor cell

KW - tissue scaling

KW - turbinate

UR - http://www.scopus.com/inward/record.url?scp=85053802241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053802241&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2018.07.010

DO - 10.1016/j.devcel.2018.07.010

M3 - Article

C2 - 30100263

AN - SCOPUS:85053802241

VL - 46

SP - 564-580.e5

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 5

ER -