FGF signaling: Diverse roles during cochlear development

Michael Ebeid, Sung-Ho Huh

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

Original languageEnglish (US)
Pages (from-to)487-495
Number of pages9
JournalBMB Reports
Volume50
Issue number10
DOIs
StatePublished - Jan 1 2017

    Fingerprint

Keywords

  • Cochlea
  • FGF signaling
  • Hair cells
  • Inner ear development
  • Sensory progenitor cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this