FGF signaling

Diverse roles during cochlear development

Michael Ebeid, Sung-Ho Huh

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

Original languageEnglish (US)
Pages (from-to)487-495
Number of pages9
JournalBMB Reports
Volume50
Issue number10
DOIs
StatePublished - 2017

Fingerprint

Cochlea
Inner Ear
Saccule and Utricle
Organ of Corti
Semicircular Canals
Rhombencephalon
Ectoderm
Morphogenesis
Canals
Epithelium
Cells
Acoustic waves

Keywords

  • Cochlea
  • FGF signaling
  • Hair cells
  • Inner ear development
  • Sensory progenitor cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

FGF signaling : Diverse roles during cochlear development. / Ebeid, Michael; Huh, Sung-Ho.

In: BMB Reports, Vol. 50, No. 10, 2017, p. 487-495.

Research output: Contribution to journalShort survey

Ebeid, Michael ; Huh, Sung-Ho. / FGF signaling : Diverse roles during cochlear development. In: BMB Reports. 2017 ; Vol. 50, No. 10. pp. 487-495.
@article{49b47c695f9a4a23ac19630665233c99,
title = "FGF signaling: Diverse roles during cochlear development",
abstract = "Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.",
keywords = "Cochlea, FGF signaling, Hair cells, Inner ear development, Sensory progenitor cells",
author = "Michael Ebeid and Sung-Ho Huh",
year = "2017",
doi = "10.5483/BMBRep.2017.50.10.164",
language = "English (US)",
volume = "50",
pages = "487--495",
journal = "BMB Reports",
issn = "1976-6696",
publisher = "The Biochemical Society of the Republic of Korea",
number = "10",

}

TY - JOUR

T1 - FGF signaling

T2 - Diverse roles during cochlear development

AU - Ebeid, Michael

AU - Huh, Sung-Ho

PY - 2017

Y1 - 2017

N2 - Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

AB - Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

KW - Cochlea

KW - FGF signaling

KW - Hair cells

KW - Inner ear development

KW - Sensory progenitor cells

UR - http://www.scopus.com/inward/record.url?scp=85032505860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032505860&partnerID=8YFLogxK

U2 - 10.5483/BMBRep.2017.50.10.164

DO - 10.5483/BMBRep.2017.50.10.164

M3 - Short survey

VL - 50

SP - 487

EP - 495

JO - BMB Reports

JF - BMB Reports

SN - 1976-6696

IS - 10

ER -