Fetal alcohol syndrome and secondary schizophrenia

A unique neuropathologic study

Catherine Stoos, Laura Nelsen, Kathryn A. Schissler, Amy Elliott, Hannah C. Kinney

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalJournal of Child Neurology
Volume30
Issue number5
DOIs
StatePublished - Apr 27 2015
Externally publishedYes

Fingerprint

Fetal Alcohol Spectrum Disorders
Temporal Lobe
Schizophrenia
Poisons
Psychiatry
Alcohols
Parturition
Pathology
Pregnancy
Brain

Keywords

  • areal patterning
  • schizophrenia
  • superior temporal gyrus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Fetal alcohol syndrome and secondary schizophrenia : A unique neuropathologic study. / Stoos, Catherine; Nelsen, Laura; Schissler, Kathryn A.; Elliott, Amy; Kinney, Hannah C.

In: Journal of Child Neurology, Vol. 30, No. 5, 27.04.2015, p. 601-605.

Research output: Contribution to journalArticle

Stoos, Catherine ; Nelsen, Laura ; Schissler, Kathryn A. ; Elliott, Amy ; Kinney, Hannah C. / Fetal alcohol syndrome and secondary schizophrenia : A unique neuropathologic study. In: Journal of Child Neurology. 2015 ; Vol. 30, No. 5. pp. 601-605.
@article{b252b47b45d645a3a061b66302168a19,
title = "Fetal alcohol syndrome and secondary schizophrenia: A unique neuropathologic study",
abstract = "We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.",
keywords = "areal patterning, schizophrenia, superior temporal gyrus",
author = "Catherine Stoos and Laura Nelsen and Schissler, {Kathryn A.} and Amy Elliott and Kinney, {Hannah C.}",
year = "2015",
month = "4",
day = "27",
doi = "10.1177/0883073814520976",
language = "English (US)",
volume = "30",
pages = "601--605",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Fetal alcohol syndrome and secondary schizophrenia

T2 - A unique neuropathologic study

AU - Stoos, Catherine

AU - Nelsen, Laura

AU - Schissler, Kathryn A.

AU - Elliott, Amy

AU - Kinney, Hannah C.

PY - 2015/4/27

Y1 - 2015/4/27

N2 - We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.

AB - We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.

KW - areal patterning

KW - schizophrenia

KW - superior temporal gyrus

UR - http://www.scopus.com/inward/record.url?scp=84925652619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925652619&partnerID=8YFLogxK

U2 - 10.1177/0883073814520976

DO - 10.1177/0883073814520976

M3 - Article

VL - 30

SP - 601

EP - 605

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 5

ER -