Ferulic acid Dimer as a non-opioid therapeutic for acute pain

Alaini Priebe, Megan Hunke, Raquel Tonello, Yogesh Sonawane, Temugin Berta, Amarnath Natarajan, Nattamai Bhuvanesh, Mahesh Pattabiraman, Surabhi Chandra

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Search for alternate pain medications has gained more importance in the past few years due to adverse effects associated with currently prescribed drugs including nervous system dysfunction with opioids, gastrointestinal discomfort with nonsteroidal anti-inflammatory drugs, and cardiovascular anomalies with cyclooxygenase-2 (COX-2) inhibitors. Phytomedicine has been explored for the treatment of pain, as these have been used for generations in regional communities and tend to lack major side effects in general. One such phytomedicine, incarvillateine (INCA), derived from the Chinese herb Incarvillea sinensis has its primary antinociceptive action through the adenosine receptor, a novel pain target. We hypothesized that derivatives of cinnamic acid dimers, which are structurally similar to INCA, would show potent antinociceptive action and that their effect would be mediated through adenosine receptor action. Materials and methods: Dimers of cinnamic acid (INCA analogs) were synthesized using cavitand-mediated photodimerization (CMP) method, which utilizes a macromolecule (γ-cyclodextrin) to control excited state reactivity of photoactive compounds. Acute pain response was assessed by using formalin-induced licking behavior in hind paw of mice, and neurologic function was monitored through locomotor activity, mechanical hyperalgesia, and thermal sensitivity upon administration of test compound. For mechanistic studies, binding to adenosine receptor was determined by using computer modeling. Results: Ferulic acid dimer (FAD), which has the same chemical functionalities on the aromatic ring as INCA, showed significant suppression of formalin-induced acute pain. Antinociceptive effect was observed primarily in the inflammatory phase, and no apparent behavioral changes related to the nervous system were noticeable. Inhibition of opioid receptor did not reverse antinociceptive response, and modeling data suggest adenosine 3 receptor binding. Conclusion: FAD (INCA analog) shows potent nonopioid antinociceptive action mediated predominantly through A3AR - adenosine 3 receptor action. Further characterization and selection of such INCA analogs will help us generate a new class of antinociceptives with precise chemical modifications by using CMP methodology.

Original languageEnglish (US)
Pages (from-to)1075-1085
Number of pages11
JournalJournal of Pain Research
Volume11
DOIs
StatePublished - Jun 6 2018

Fingerprint

ferulic acid
Acute Pain
Purinergic P1 Receptors
Nervous System
Pain
Formaldehyde
Therapeutics
Cardiovascular Agents
Cyclooxygenase 2 Inhibitors
Hyperalgesia
Cyclodextrins
Opioid Receptors
Locomotion
Opioid Analgesics
incarvillateine
Anti-Inflammatory Agents
Hot Temperature

Keywords

  • Adenosine
  • Antinociceptive
  • Cinnamic acid
  • Formalin
  • Incarvillateine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Ferulic acid Dimer as a non-opioid therapeutic for acute pain. / Priebe, Alaini; Hunke, Megan; Tonello, Raquel; Sonawane, Yogesh; Berta, Temugin; Natarajan, Amarnath; Bhuvanesh, Nattamai; Pattabiraman, Mahesh; Chandra, Surabhi.

In: Journal of Pain Research, Vol. 11, 06.06.2018, p. 1075-1085.

Research output: Contribution to journalArticle

Priebe, Alaini ; Hunke, Megan ; Tonello, Raquel ; Sonawane, Yogesh ; Berta, Temugin ; Natarajan, Amarnath ; Bhuvanesh, Nattamai ; Pattabiraman, Mahesh ; Chandra, Surabhi. / Ferulic acid Dimer as a non-opioid therapeutic for acute pain. In: Journal of Pain Research. 2018 ; Vol. 11. pp. 1075-1085.
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AU - Natarajan, Amarnath

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AU - Pattabiraman, Mahesh

AU - Chandra, Surabhi

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