Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system

S. J. Henriksen, O. Prospero-Garcia, T. R. Phillips, H. S. Fox, F. E. Bloom, J. H. Elder

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Abstract

Feline immunodeficiency virus infects the CNS and results in predictable pathophysiology strikingly similar to that seen with HIV-1 infection of humans. The observed pathophysiology is mimicked in several physiologically assessed modalities, further supporting the validity of the feline model. Peripheral and control evoked potential findings and the occurrence of the sleep architecture changes in both cat and human disease provide an intriguing focus for further investigation. Although structurally diverse in an absolute sense, FIV and HIV-1 share basic structural features and commonalities of their life cycle. It is likely that by understanding the common mechanisms by which these lentiviruses influence CNS function, a more complete understanding of the neurological deficits seen in HIV-1-infected patients will be obtained. The cat model is particularly valuable for study of CNS disease, since it allows detailed analyses of events during the acute phase of infection, under circumstances in which the nature and timing of the infection are carefully controlled. The availability of molecular clones for mutational analysis will facilitate mapping of genomic regions critical to the perturbation of CNS function. It is suggested that development of intervention strategies in the cat model will yield treatment modalities directly applicable to HIV-1 infection of humans.

Original languageEnglish (US)
Pages (from-to)167-186
Number of pages20
JournalCurrent topics in microbiology and immunology
Volume202
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Henriksen, S. J., Prospero-Garcia, O., Phillips, T. R., Fox, H. S., Bloom, F. E., & Elder, J. H. (1995). Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system. Current topics in microbiology and immunology, 202, 167-186.