Feeding immunity: Physiological and behavioral responses to infection and resource limitation

Sarah A. Budischak, Christina B. Hansen, Quentin Caudron, Romain Garnier, Tyler R. Kartzinel, István Pelczer, Clayton E. Cressler, Anieke van Leeuwen, Andrea L. Graham

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Resources are a core currency of species interactions and ecology in general (e.g., think of food webs or competition). Within parasite-infected hosts, resources are divided among the competing demands of host immunity and growth as well as parasite reproduction and growth. Effects of resources on immune responses are increasingly understood at the cellular level (e.g., metabolic predictors of effector function), but there has been limited consideration of how these effects scale up to affect individual energetic regimes (e.g., allocation trade-offs), susceptibility to infection, and feeding behavior (e.g., responses to local resource quality and quantity). We experimentally rewilded laboratory mice (strain C57BL/6) in semi-natural enclosures to investigate the effects of dietary protein and gastrointestinal nematode (Trichuris muris) infection on individual-level immunity, activity, and behavior. The scale and realism of this field experiment, as well as the multiple physiological assays developed for laboratory mice, enabled us to detect costs, trade-offs, and potential compensatory mechanisms that mice employ to battle infection under different resource conditions. We found that mice on a low-protein diet spent more time feeding, which led to higher body fat stores (i.e., concentration of a satiety hormone, leptin) and altered metabolite profiles, but which did not fully compensate for the effects of poor nutrition on albumin or immune defenses. Specifically, immune defenses measured as interleukin 13 (IL13) (a primary cytokine coordinating defense against T. muris) and as T. muris-specific IgG1 titers were lower in mice on the low-protein diet. However, these reduced defenses did not result in higher worm counts in mice with poorer diets. The lab mice, living outside for the first time in thousands of generations, also consumed at least 26 wild plant species occurring in the enclosures, and DNA metabarcoding revealed that the consumption of different wild foods may be associated with differences in leptin concentrations. When individual foraging behavior was accounted for, worm infection significantly reduced rates of host weight gain. Housing laboratory mice in outdoor enclosures provided new insights into the resource costs of immune defense to helminth infection and how hosts modify their behavior to compensate for those costs.

Original languageEnglish (US)
Article number1914
JournalFrontiers in immunology
Volume8
Issue numberDEC
DOIs
StatePublished - Jan 8 2018

Fingerprint

Immunity
Infection
Protein-Restricted Diet
Leptin
Costs and Cost Analysis
Parasites
Trichuris
Food Chain
Interleukin-13
Dietary Proteins
Helminths
Feeding Behavior
Growth
Ecology
Weight Gain
Reproduction
Adipose Tissue
Albumins
Immunoglobulin G
Hormones

Keywords

  • Compensatory feeding
  • DNA metabarcoding
  • Nuclear magnetic resonance spectroscopy metabolite profiling
  • Resource-immune trade-offs
  • Rewilding mice
  • Trichuris muris

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Budischak, S. A., Hansen, C. B., Caudron, Q., Garnier, R., Kartzinel, T. R., Pelczer, I., ... Graham, A. L. (2018). Feeding immunity: Physiological and behavioral responses to infection and resource limitation. Frontiers in immunology, 8(DEC), [1914]. https://doi.org/10.3389/fimmu.2017.01914

Feeding immunity : Physiological and behavioral responses to infection and resource limitation. / Budischak, Sarah A.; Hansen, Christina B.; Caudron, Quentin; Garnier, Romain; Kartzinel, Tyler R.; Pelczer, István; Cressler, Clayton E.; Leeuwen, Anieke van; Graham, Andrea L.

In: Frontiers in immunology, Vol. 8, No. DEC, 1914, 08.01.2018.

Research output: Contribution to journalArticle

Budischak, SA, Hansen, CB, Caudron, Q, Garnier, R, Kartzinel, TR, Pelczer, I, Cressler, CE, Leeuwen, AV & Graham, AL 2018, 'Feeding immunity: Physiological and behavioral responses to infection and resource limitation', Frontiers in immunology, vol. 8, no. DEC, 1914. https://doi.org/10.3389/fimmu.2017.01914
Budischak SA, Hansen CB, Caudron Q, Garnier R, Kartzinel TR, Pelczer I et al. Feeding immunity: Physiological and behavioral responses to infection and resource limitation. Frontiers in immunology. 2018 Jan 8;8(DEC). 1914. https://doi.org/10.3389/fimmu.2017.01914
Budischak, Sarah A. ; Hansen, Christina B. ; Caudron, Quentin ; Garnier, Romain ; Kartzinel, Tyler R. ; Pelczer, István ; Cressler, Clayton E. ; Leeuwen, Anieke van ; Graham, Andrea L. / Feeding immunity : Physiological and behavioral responses to infection and resource limitation. In: Frontiers in immunology. 2018 ; Vol. 8, No. DEC.
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