Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease

Megan C. Niederwerder, Laura A. Constance, Raymond R.R. Rowland, Waseem Abbas, Samodha C Fernando, Megan L. Potter, Maureen A. Sheahan, Thomas E Burkey, Richard A. Hesse, Ada G. Cino-Ozuna

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Porcine circovirus associated disease (PCVAD) is a term used to describe the multi-factorial disease syndromes caused by porcine circovirus type 2 (PCV-2), which can be reproduced in an experimental setting through the co-infection of pigs with PCV-2 and porcine reproductive and respiratory syndrome virus (PRRSV). The resulting PCVAD-affected pigs represent a subpopulation within the co-infected group. In co-infection studies, the presence of increased microbiome diversity is linked to a reduction in clinical signs. In this study, fecal microbiota transplantation (FMT) was investigated as a means to prevent PCVAD in pigs co-infected with PRRSV and PCV-2d. The sources of the FMT material were high-parity sows with a documented history of high health status and robust litter characteristics. The analysis of the donated FMT material showed the absence of common pathogens along with the presence of diverse microbial phyla and families. One group of pigs (n = 10) was administered the FMT while a control group (n = 10) was administered a sterile mock-transplant. Over the 42-day post-infection period, the FMT group showed fewer PCVAD-affected pigs, as evidenced by a significant reduction in morbidity and mortality in transplanted pigs, along with increased antibody levels. Overall, this study provides evidence that FMT decreases the severity of clinical signs following co-infection with PRRSV and PCV-2 by reducing the prevalence of PCVAD.

Original languageEnglish (US)
Article number1631
JournalFrontiers in Microbiology
Volume9
Issue numberJUL
DOIs
StatePublished - Jul 23 2018

Fingerprint

Circovirus
Morbidity
Swine
Mortality
Porcine respiratory and reproductive syndrome virus
Coinfection
Fecal Microbiota Transplantation
Microbiota
Parity
Health Status
Transplants
Control Groups
Antibodies

Keywords

  • Fecal microbiota transplantation
  • Microbiome
  • Porcine circovirus associated disease
  • Porcine circovirus type 2
  • Porcine reproductive and respiratory syndrome virus
  • Swine

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease. / Niederwerder, Megan C.; Constance, Laura A.; Rowland, Raymond R.R.; Abbas, Waseem; Fernando, Samodha C; Potter, Megan L.; Sheahan, Maureen A.; Burkey, Thomas E; Hesse, Richard A.; Cino-Ozuna, Ada G.

In: Frontiers in Microbiology, Vol. 9, No. JUL, 1631, 23.07.2018.

Research output: Contribution to journalArticle

Niederwerder, MC, Constance, LA, Rowland, RRR, Abbas, W, Fernando, SC, Potter, ML, Sheahan, MA, Burkey, TE, Hesse, RA & Cino-Ozuna, AG 2018, 'Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease', Frontiers in Microbiology, vol. 9, no. JUL, 1631. https://doi.org/10.3389/fmicb.2018.01631
Niederwerder, Megan C. ; Constance, Laura A. ; Rowland, Raymond R.R. ; Abbas, Waseem ; Fernando, Samodha C ; Potter, Megan L. ; Sheahan, Maureen A. ; Burkey, Thomas E ; Hesse, Richard A. ; Cino-Ozuna, Ada G. / Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease. In: Frontiers in Microbiology. 2018 ; Vol. 9, No. JUL.
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