Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient

K. Neemann, D. D D Eichele, P. P W Smith, Robert G Bociek, M. Akhtari, Alison Gail Freifeld

Research output: Contribution to journalArticle

72 Scopus citations


We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.

Original languageEnglish (US)
Pages (from-to)E161-E165
JournalTransplant Infectious Disease
Issue number6
StatePublished - Dec 1 2012



  • Clostridium difficile infection
  • Fecal microbiota therapy
  • Fecal transplant

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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