Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient

K. Neemann, D. D D Eichele, P. P W Smith, Robert G Bociek, M. Akhtari, Alison Gail Freifeld

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.

Original languageEnglish (US)
JournalTransplant Infectious Disease
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Clostridium Infections
Clostridium difficile
Stem Cells
Microbiota
Transplants
Therapeutics
Immunocompromised Host
Hematopoietic Stem Cells
Fecal Microbiota Transplantation
Tissue Donors

Keywords

  • Clostridium difficile infection
  • Fecal microbiota therapy
  • Fecal transplant

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient. / Neemann, K.; Eichele, D. D D; Smith, P. P W; Bociek, Robert G; Akhtari, M.; Freifeld, Alison Gail.

In: Transplant Infectious Disease, Vol. 14, No. 6, 01.12.2012.

Research output: Contribution to journalArticle

@article{c09fbdbd35dd4e188423a4b51c88a134,
title = "Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient",
abstract = "We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.",
keywords = "Clostridium difficile infection, Fecal microbiota therapy, Fecal transplant",
author = "K. Neemann and Eichele, {D. D D} and Smith, {P. P W} and Bociek, {Robert G} and M. Akhtari and Freifeld, {Alison Gail}",
year = "2012",
month = "12",
day = "1",
doi = "10.1111/tid.12017",
language = "English (US)",
volume = "14",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient

AU - Neemann, K.

AU - Eichele, D. D D

AU - Smith, P. P W

AU - Bociek, Robert G

AU - Akhtari, M.

AU - Freifeld, Alison Gail

PY - 2012/12/1

Y1 - 2012/12/1

N2 - We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.

AB - We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.

KW - Clostridium difficile infection

KW - Fecal microbiota therapy

KW - Fecal transplant

UR - http://www.scopus.com/inward/record.url?scp=84871026100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871026100&partnerID=8YFLogxK

U2 - 10.1111/tid.12017

DO - 10.1111/tid.12017

M3 - Article

VL - 14

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 6

ER -