Feasibility and reproducibility of substituting oral contrast with water for duodenal volume delineation in patients undergoing pancreatic stereotactic body radiotherapy

Guangyin Wu, Vivek Verma, Matthias F. Haefner, Sicong Li, Chi Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). Methods: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation. Comparison was made to 40 patients treated from January 2009 to February 2012 on a prospective trial who used oral contrast. Group comparisons were performed by the Mann-Whitney U test. Results: The duodenum was identified in all 13 patients who used water instead of oral contrast without subjective difficulty. In this group, the median duodenal volume was 72.86 cm3 (range, 44.61-130.90 cm3). In the oral contrast group, median duodenal volume was 86.21 cm3 (range, 50.11-157.89 cm3) There were no significant differences between groups (P=0.115). The approach was reproducible, as all patients were able to drink the same amount of water 15-20 min prior to each SBRT fraction to keep duodenal volumes subjectively similar to volumes on the simulation CT scan. Conclusions: This novel approach is effective and reproducible in delineating the duodenum for treatment planning and daily setup.

Original languageEnglish (US)
Pages (from-to)705-709
Number of pages5
JournalJournal of Gastrointestinal Oncology
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Radiosurgery
Duodenum
Water
Nonparametric Statistics
Eating
Therapeutics

Keywords

  • Duodenum
  • Pancreatic cancer
  • Stereotactic ablative radiotherapy
  • Stereotactic body radiotherapy (SBRT)
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

@article{8f13a339fdad4516a9da7478a51e80d5,
title = "Feasibility and reproducibility of substituting oral contrast with water for duodenal volume delineation in patients undergoing pancreatic stereotactic body radiotherapy",
abstract = "Background: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). Methods: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation. Comparison was made to 40 patients treated from January 2009 to February 2012 on a prospective trial who used oral contrast. Group comparisons were performed by the Mann-Whitney U test. Results: The duodenum was identified in all 13 patients who used water instead of oral contrast without subjective difficulty. In this group, the median duodenal volume was 72.86 cm3 (range, 44.61-130.90 cm3). In the oral contrast group, median duodenal volume was 86.21 cm3 (range, 50.11-157.89 cm3) There were no significant differences between groups (P=0.115). The approach was reproducible, as all patients were able to drink the same amount of water 15-20 min prior to each SBRT fraction to keep duodenal volumes subjectively similar to volumes on the simulation CT scan. Conclusions: This novel approach is effective and reproducible in delineating the duodenum for treatment planning and daily setup.",
keywords = "Duodenum, Pancreatic cancer, Stereotactic ablative radiotherapy, Stereotactic body radiotherapy (SBRT), Toxicity",
author = "Guangyin Wu and Vivek Verma and Haefner, {Matthias F.} and Sicong Li and Chi Lin",
year = "2017",
month = "8",
day = "1",
doi = "10.21037/jgo.2017.04.03",
language = "English (US)",
volume = "8",
pages = "705--709",
journal = "Journal of Gastrointestinal Oncology",
issn = "2078-6891",
publisher = "Pioneer Bioscience Publishing Company (PBPC)",
number = "4",

}

TY - JOUR

T1 - Feasibility and reproducibility of substituting oral contrast with water for duodenal volume delineation in patients undergoing pancreatic stereotactic body radiotherapy

AU - Wu, Guangyin

AU - Verma, Vivek

AU - Haefner, Matthias F.

AU - Li, Sicong

AU - Lin, Chi

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). Methods: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation. Comparison was made to 40 patients treated from January 2009 to February 2012 on a prospective trial who used oral contrast. Group comparisons were performed by the Mann-Whitney U test. Results: The duodenum was identified in all 13 patients who used water instead of oral contrast without subjective difficulty. In this group, the median duodenal volume was 72.86 cm3 (range, 44.61-130.90 cm3). In the oral contrast group, median duodenal volume was 86.21 cm3 (range, 50.11-157.89 cm3) There were no significant differences between groups (P=0.115). The approach was reproducible, as all patients were able to drink the same amount of water 15-20 min prior to each SBRT fraction to keep duodenal volumes subjectively similar to volumes on the simulation CT scan. Conclusions: This novel approach is effective and reproducible in delineating the duodenum for treatment planning and daily setup.

AB - Background: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). Methods: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation. Comparison was made to 40 patients treated from January 2009 to February 2012 on a prospective trial who used oral contrast. Group comparisons were performed by the Mann-Whitney U test. Results: The duodenum was identified in all 13 patients who used water instead of oral contrast without subjective difficulty. In this group, the median duodenal volume was 72.86 cm3 (range, 44.61-130.90 cm3). In the oral contrast group, median duodenal volume was 86.21 cm3 (range, 50.11-157.89 cm3) There were no significant differences between groups (P=0.115). The approach was reproducible, as all patients were able to drink the same amount of water 15-20 min prior to each SBRT fraction to keep duodenal volumes subjectively similar to volumes on the simulation CT scan. Conclusions: This novel approach is effective and reproducible in delineating the duodenum for treatment planning and daily setup.

KW - Duodenum

KW - Pancreatic cancer

KW - Stereotactic ablative radiotherapy

KW - Stereotactic body radiotherapy (SBRT)

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85027349823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027349823&partnerID=8YFLogxK

U2 - 10.21037/jgo.2017.04.03

DO - 10.21037/jgo.2017.04.03

M3 - Article

C2 - 28890821

AN - SCOPUS:85027349823

VL - 8

SP - 705

EP - 709

JO - Journal of Gastrointestinal Oncology

JF - Journal of Gastrointestinal Oncology

SN - 2078-6891

IS - 4

ER -