Fatty acyl CoA esters as regulators of cell metabolism

E. Shrago, G. Woldegiorgis, A. E. Ruoho, Concetta C DiRusso

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Long chain fatty acyl CoA esters have the ability to interact with certain proteins and thereby serve as effectors in cell metabolism. In particular, they can displace nucleotides from specific nucleotide dependent or binding proteins and interfere with their action. The ADP/ATP carrier and uncoupling protein are two examples where the interplay of nucleotide and acyl CoA binding to the proteins regulate their function. Other proteins such as glucokinase can be considered in this group. In certain tissues like liver they are affected during fasting and insulin deficiency, and when serum fatty acids and liver acyl CoA levels are elevated. More recently, an acyl CoA binding protein in E. coli has been found to be a transcription factor for gene regulation of fatty acid metabolism enzymes. There appears to be some consensus in the amino acid sequence for acyl CoA binding sites on these proteins which serve a variety of important roles in cellular metabolism.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume52
Issue number2-3
DOIs
StatePublished - Jan 1 1995

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Acyl Coenzyme A
Metabolism
Esters
Diazepam Binding Inhibitor
Nucleotides
Carrier Proteins
Proteins
Fatty Acids
Liver
ATP Translocases Mitochondrial ADP
Glucokinase
Aptitude
Fatty Liver
Amino Acid Sequence
Fasting
Consensus
Transcription Factors
Gene expression
Binding Sites
Escherichia coli

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

Fatty acyl CoA esters as regulators of cell metabolism. / Shrago, E.; Woldegiorgis, G.; Ruoho, A. E.; DiRusso, Concetta C.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 52, No. 2-3, 01.01.1995, p. 163-166.

Research output: Contribution to journalArticle

Shrago, E. ; Woldegiorgis, G. ; Ruoho, A. E. ; DiRusso, Concetta C. / Fatty acyl CoA esters as regulators of cell metabolism. In: Prostaglandins, Leukotrienes and Essential Fatty Acids. 1995 ; Vol. 52, No. 2-3. pp. 163-166.
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