Fate of patients with a "Surprise" positive culture after nonunion surgery

Dana Olszewski, Philipp N Streubel, Charlton Stucken, William M. Ricci, Martin F. Hoffmann, Clifford B. Jones, Debra L. Sietsema, Paul Tornetta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Review the impact of unexpected positive cultures from definitive surgery for nonunion regarding postoperative treatment and ultimate result. Designs: Retrospective multicenter case series. Setting: Three level-one trauma centers. Patients: Six-hundred sixty-six consecutive nonunions were treated during the study period. Four-hundred fifty-three cases (68%) were considered at risk for indolent infection (prior open fracture, surgery, or infection) and had cultures taken at the time of definitive surgery. Intervention: Intraoperative cultures during definitive operative treatment of nonunions. Main Outcome Measurement: The incidence of "surprise" positive cultures was determined, and the course of the patients was documented including the use of antibiotics, surgery performed, and the outcome regarding infection and union. Results: Ninety-one (20%) cases had a surprise positive culture despite negative inflammatory markers. Most of bacteria isolated from the cultures were Staphylococcus species. Eight (9%) of the ninety-one cultures were considered probable contaminants and no antibiotics were given, 5 of these patients healed. The other 83 patients were treated with antibiotics, initially 66 (80%) healed and 12 (14%) remained infected. Eighty-two percent of patients with augmentation healed as compared with 86% of those not grafted. Conclusions: The treatment of nonunions is challenging, and in patients with a history of surgery or open fracture, we found that 20% had positive intraoperative cultures from the definitive surgery. We recommend intraoperative cultures for all patients undergoing revision surgery. The use of culture-specific antibiotics is justified based on the overall low rate of infection in this complex population and the high rate of chronic infection (25%) for those treated as contaminants. Patients may be counseled that a positive culture after nonunion surgery is a treatable problem but does increase the risk of infection and additional surgery as compared with those with a negative intraoperative culture.

Original languageEnglish (US)
Pages (from-to)e19-e23
JournalJournal of Orthopaedic Trauma
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2016

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Infection
Anti-Bacterial Agents
Open Fractures
Trauma Centers
Staphylococcus
Reoperation
Therapeutics
Bacteria
Incidence
Population

Keywords

  • bacteria
  • culture
  • grafting
  • infection
  • nonunion

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Olszewski, D., Streubel, P. N., Stucken, C., Ricci, W. M., Hoffmann, M. F., Jones, C. B., ... Tornetta, P. (2016). Fate of patients with a "Surprise" positive culture after nonunion surgery. Journal of Orthopaedic Trauma, 30(1), e19-e23. https://doi.org/10.1097/BOT.0000000000000417

Fate of patients with a "Surprise" positive culture after nonunion surgery. / Olszewski, Dana; Streubel, Philipp N; Stucken, Charlton; Ricci, William M.; Hoffmann, Martin F.; Jones, Clifford B.; Sietsema, Debra L.; Tornetta, Paul.

In: Journal of Orthopaedic Trauma, Vol. 30, No. 1, 01.01.2016, p. e19-e23.

Research output: Contribution to journalArticle

Olszewski, D, Streubel, PN, Stucken, C, Ricci, WM, Hoffmann, MF, Jones, CB, Sietsema, DL & Tornetta, P 2016, 'Fate of patients with a "Surprise" positive culture after nonunion surgery', Journal of Orthopaedic Trauma, vol. 30, no. 1, pp. e19-e23. https://doi.org/10.1097/BOT.0000000000000417
Olszewski, Dana ; Streubel, Philipp N ; Stucken, Charlton ; Ricci, William M. ; Hoffmann, Martin F. ; Jones, Clifford B. ; Sietsema, Debra L. ; Tornetta, Paul. / Fate of patients with a "Surprise" positive culture after nonunion surgery. In: Journal of Orthopaedic Trauma. 2016 ; Vol. 30, No. 1. pp. e19-e23.
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abstract = "Objective: Review the impact of unexpected positive cultures from definitive surgery for nonunion regarding postoperative treatment and ultimate result. Designs: Retrospective multicenter case series. Setting: Three level-one trauma centers. Patients: Six-hundred sixty-six consecutive nonunions were treated during the study period. Four-hundred fifty-three cases (68{\%}) were considered at risk for indolent infection (prior open fracture, surgery, or infection) and had cultures taken at the time of definitive surgery. Intervention: Intraoperative cultures during definitive operative treatment of nonunions. Main Outcome Measurement: The incidence of {"}surprise{"} positive cultures was determined, and the course of the patients was documented including the use of antibiotics, surgery performed, and the outcome regarding infection and union. Results: Ninety-one (20{\%}) cases had a surprise positive culture despite negative inflammatory markers. Most of bacteria isolated from the cultures were Staphylococcus species. Eight (9{\%}) of the ninety-one cultures were considered probable contaminants and no antibiotics were given, 5 of these patients healed. The other 83 patients were treated with antibiotics, initially 66 (80{\%}) healed and 12 (14{\%}) remained infected. Eighty-two percent of patients with augmentation healed as compared with 86{\%} of those not grafted. Conclusions: The treatment of nonunions is challenging, and in patients with a history of surgery or open fracture, we found that 20{\%} had positive intraoperative cultures from the definitive surgery. We recommend intraoperative cultures for all patients undergoing revision surgery. The use of culture-specific antibiotics is justified based on the overall low rate of infection in this complex population and the high rate of chronic infection (25{\%}) for those treated as contaminants. Patients may be counseled that a positive culture after nonunion surgery is a treatable problem but does increase the risk of infection and additional surgery as compared with those with a negative intraoperative culture.",
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