Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation

William G. Woods, Louis P. Dehner, Mark E. Nesbit, William Krivit, Peter F. Coccia, Norma K.C. Ramsay, Tae H. Kim, John H. Kersey

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Abstract

In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalThe American journal of medicine
Volume68
Issue number2
DOIs
Publication statusPublished - Feb 1980

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ASJC Scopus subject areas

  • Medicine(all)

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Woods, W. G., Dehner, L. P., Nesbit, M. E., Krivit, W., Coccia, P. F., Ramsay, N. K. C., ... Kersey, J. H. (1980). Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation. The American journal of medicine, 68(2), 285-290. https://doi.org/10.1016/0002-9343(80)90368-X